H2S Cancer Research Results

H2S, hydrogen sulfide: Click to Expand ⟱
Source:
Type:
In the liver, H₂S is produced endogenously through the enzymatic activity of cystathionine β‐synthase (CBS), cystathionine γ‐lyase (CSE), and the mitochondrial 3-mercaptopyruvate sulfurtransferase (3-MST).

– In the liver, H₂S participates in maintaining metabolic homeostasis and controlling oxidative stress, with a dual role depending on its concentration and context.

At low-to-moderate levels, H₂S generally supports cytoprotection, angiogenesis, and pro-survival pathways. In contrast, high levels of H₂S can trigger oxidative stress and cytotoxicit.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2272- dietMet,    Methionine restriction - Association with redox homeostasis and implications on aging and diseases
- Review, Nor, NA
*OS↑, *mt-ROS↓, *H2S↑, *FGF21↑, *cognitive↑, *GutMicro↑, *IGF-1↓, *mTOR↓, *GSH↑, *SOD↑, *MDA↓, *NRF2↑, *HO-1↑, *NQO1↑, *GLUT4↑, *Glycolysis↑, *HK2↑, *PFK↑, *PKM2↑, *GlucoseCon↑, *ATF4↑, *PPARα↑, GSH↓, GSTs↑, ROS↑, *neuroP↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,   GSTs↑, 1,   ROS↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   HO-1↑, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   mt-ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

FGF21↑, 1,   GlucoseCon↑, 1,   Glycolysis↑, 1,   H2S↑, 1,   HK2↑, 1,   PFK↑, 1,   PKM2↑, 1,   PPARα↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   mTOR↓, 1,  

Angiogenesis & Vasculature ⓘ

ATF4↑, 1,  

Barriers & Transport ⓘ

GLUT4↑, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

cognitive↑, 1,   neuroP↑, 1,   OS↑, 1,  
Total Targets: 23

Scientific Paper Hit Count for: H2S, hydrogen sulfide
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1281  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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