SIRT2 Cancer Research Results

SIRT2, Sirtuin 2: Click to Expand ⟱
Source:
Type:
SIRT2 is primarily localized in the cytoplasm but can also shuttle into the nucleus, where it regulates multiple cellular functions.
It deacetylates various substrates including histones and non-histone proteins, thereby influencing gene expression, cell cycle progression, and cytoskeletal dynamics.
SIRT2’s enzymatic activity is dependent on NAD⁺ levels, linking its function to the metabolic state of the cell.

Lower expression levels often correlate with more aggressive disease and poorer prognosis in certain contexts, although some studies suggest that overexpression can also be deleterious in specific settings.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2931- NAD,    NAD+ Repletion Rescues Female Fertility during Reproductive Aging
- in-vivo, Nor, NA
*eff↑, *SIRT2↑, *other↑, *Dose↝,
2333- RES,    Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
- in-vitro, Nor, NA
*glucose↓, *Insulin↓, *IGFR↓, *IGF-1↓, *LDHA↑, *HK2↑, *PKM2↑, *Glycolysis↝, *SIRT2↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Mitochondria & Bioenergetics ⓘ

Insulin↓, 1,  

Core Metabolism/Glycolysis ⓘ

glucose↓, 1,   Glycolysis↝, 1,   HK2↑, 1,   LDHA↑, 1,   PKM2↑, 1,   SIRT2↑, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   IGFR↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 1,  
Total Targets: 12

Scientific Paper Hit Count for: SIRT2, Sirtuin 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1289  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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