GPx1 Cancer Research Results

GPx1, Glutathione Peroxidase: Click to Expand ⟱
Source:
Type:
Widely and abundantly expressed antioxidant enzyme
Glutathione peroxidase (GPx) is an important antioxidant enzyme that plays a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. It utilizes glutathione, a tripeptide composed of glutamine, cysteine, and glycine, as a substrate to carry GPx is part of the body's antioxidant defense system. By reducing oxidative stress, GPx may help prevent the initiation and progression of cancer. Some studies suggest that higher levels of GPx activity are associated with a lower risk of certain cancers.
The tumor microenvironment is often characterized by increased oxidative stress. GPx can influence the behavior of cancer cells and their interactions with surrounding cells. In some cases, cancer cells may upregulate GPx to survive in this oxidative environment, which can contribute to tumor growth and resistance Inhibiting GPx in certain cancer types may sensitize tumor cells to chemotherapy and radiation therapy by increasing oxidative stress.to therapy.

GPX1 is widely expressed in various tissues and is particularly important in maintaining cellular redox balance. GPX1 expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2249- MF,    Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study
- in-vitro, Nor, L929
*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,
525- MF,    Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis
- in-vitro, Nor, HUVECs
*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,
4613- Se,  Rad,    Effect of Selenium and Selenoproteins on Radiation Resistance
- Review, Nor, NA
*selenoP↑, *GPx1↑, *GPx4↑, *lipid-P↓, *DNAdam↓, *ROS↓, *radioP↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GPx1↑, 3,   GPx4↑, 3,   lipid-P↓, 1,   OXPHOS↓, 2,   ROS↓, 3,   selenoP↑, 1,   SOD↑, 1,   SOD1↑, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↓, 1,   MMP↝, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↑, 2,   HK2↑, 2,   PFKL↑, 2,   PFKM↑, 2,   PFKP↑, 1,   PKM2↑, 2,  

Transcription & Epigenetics ⓘ

other↝, 1,   tumCV↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Migration ⓘ

TumCMig↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  

Barriers & Transport ⓘ

GLUT1↑, 2,   GLUT4↑, 1,  

Cellular Microenvironment ⓘ

pH↑, 1,  

Functional Outcomes ⓘ

radioP↑, 1,  
Total Targets: 26

Scientific Paper Hit Count for: GPx1, Glutathione Peroxidase
2 Magnetic Fields
1 Selenium
1 Radiotherapy/Radiation
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:133  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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