ARE Cancer Research Results

ARE, antioxidant responsive element (ARE): Click to Expand ⟱

Source:

Type:

antioxidant responsive element (ARE)
ARE in Normal Cells: Protective Role
ARE-regulated genes include NQO1, HO-1, GCLM, GCLC, and various glutathione S-transferases (GSTs).
-Detoxify reactive oxygen species (ROS)
-Agents like sulforaphane (from broccoli) can activate ARE in healthy cells to prevent cancer initiation.
-overactivation in cancer cells aids cancer survival, growth, resistance

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

8223-

LCA,

Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells

in-vitro,

Nor,

RAW264.7

investigated the antioxidative potential and mechanisms of Lico A against tert-butyl hydroperoxide- (t-BHP-) induced oxidative damage in RAW 264.7 cells.

*Apoptosis↓, *ROS↓, *GSH↑, *GCLM↑, *GCLC↑, *HO-1↑, *NRF2↑, *Keap1↓, *ARE↑, *Akt↑, *ERK↑, *PI3K↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress(tgid=1) ⓘ

ARE↑, 1, GCLC↑, 1, GCLM↑, 1, GSH↑, 1, HO-1↑, 1, Keap1↓, 1, NRF2↑, 1, ROS↓, 1,

Cell Death(tgid=5) ⓘ

Akt↑, 1, Apoptosis↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1, PI3K↑, 1,
Total Targets: 12

Scientific Paper Hit Count for: ARE, antioxidant responsive element (ARE)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells