VGSC Cancer Research Results

VGSC, VGNC, Na+ voltage-gated channel: Click to Expand ⟱
Source:
Type:
Voltage-gated sodium channels (VGSCs or VGNCs) (Na+ voltage-gated channel)
-aberrant expression of VGSCs occurs in many cancers, where they contribute to invasion, metastasis, and tumor aggressiveness rather than electrical signaling.
-In most cancers studied to date, voltage-gated sodium channels (VGSCs) are upregulated and hyperactive compared with normal tissue.
-Blocking VGSCs consistently reduces metastasis behaviors
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5534- MF,    Targeted Osmotic Lysis of Highly Invasive Breast Carcinomas Using Pulsed Magnetic Field Stimulation of Voltage-Gated Sodium Channels and Pharmacological Blockade of Sodium Pumps
- vitro+vivo, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumVol↓, VGSC↑, OS↑, selectivity↑, eff↑,
5535- MFrot,    Spatiotemporal magnetic fields enhance cytosolic Ca2+ levels and induce actin polymerization via activation of voltage-gated sodium channels in skeletal muscle cells
- in-vitro, Nor, NA
*Dose↝, *Vm/CMP↑, *Na+↑, *VGSC↑, *Vm/CMP↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Proliferation, Differentiation & Cell State ⓘ

VGSC↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  

Functional Outcomes ⓘ

OS↑, 1,   TumVol↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

VGSC↑, 1,  

Migration ⓘ

Na+↑, 1,  

Barriers & Transport ⓘ

Na+↑, 1,   Vm/CMP↑, 2,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 5

Scientific Paper Hit Count for: VGSC, VGNC, Na+ voltage-gated channel
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1451  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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