2/16-OHE1 Cancer Research Results

2/16-OHE1, 2-OHE1/16α-OHE1 Ratio/2-Hydroxyestrone to 16α-Hydroxyestrone Ratio: Click to Expand ⟱
Source:
Type:

2-OHE1/16α-OHE1 Ratio - 2-Hydroxyestrone to 16α-Hydroxyestrone Ratio

Abbreviation: 2/16-OHE1 ratio, 2-OHE1/16α-OHE1, EMR

Type: Estrogen metabolism biomarker / metabolite ratio

Function: Represents the relative metabolism of estrone through the 2-hydroxylation versus 16α-hydroxylation pathways. 2-Hydroxyestrone has relatively weak estrogenic activity, whereas 16α-hydroxyestrone has greater estrogenic and potentially genotoxic/proliferative activity.

Cancer: ↓ A lower 2-OHE1/16α-OHE1 ratio has historically been proposed to represent a less favorable estrogen-metabolism profile and potentially greater breast-cancer risk, while an increased ratio has been considered potentially favorable. However, prospective studies and systematic reviews have found inconsistent associations, and the ratio is not considered a validated predictor of breast-cancer risk.

Direction: ↑ Traditionally considered favorable, but clinical significance remains uncertain.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
7606- I3C,    Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol
- Human, Nor, NA
P450↝, 2/16-OHE1↑,
7611- I3C,    Long-term responses of women to indole-3-carbinol or a high fiber diet
- Trial, Nor, NA
*Dose↝, *2/16-OHE1↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

P450↝, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 2

Scientific Paper Hit Count for: 2/16-OHE1, 2-OHE1/16α-OHE1 Ratio/2-Hydroxyestrone to 16α-Hydroxyestrone Ratio
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1669  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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