6IL Cancer Research Results

6IL, 6-Iodolactone: Click to Expand ⟱

Source:

Type:

6-Iodolactone - 6-Iodo-5-Hydroxy-8,11,14-Eicosatrienoic Acid δ-Lactone

Alternative Names: 6-Iodolactone, 6IL, 6-iodo-5-hydroxy-8,11,14-eicosatrienoic acid δ-lactone

Type: Iodolipid / iodinated arachidonic-acid derivative / bioactive lipid metabolite

Formation: 6-IL is formed by iodination of arachidonic acid and has been detected in thyroid and mammary tissues following iodine exposure. Molecular iodine can increase 6-IL formation in tumor tissue containing elevated arachidonic acid.

Function: 6-Iodolactone is a bioactive iodolipid that mediates part of the antiproliferative and apoptotic effects of iodine. It acts as an activator of PPARγ and can regulate proliferation, differentiation, mitochondrial apoptosis, migration, and tumor-associated signaling.

Cancer: Preclinical studies demonstrate inhibition of tumor-cell proliferation and migration and induction of apoptosis. 6-IL activates PPARγ, and inhibition or knockdown of PPARγ substantially reduces its antiproliferative and pro-apoptotic effects. Antitumor activity has been demonstrated particularly in breast, thyroid, and prostate cancer models.

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

7678-

iod,

Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects

in-vitro,

Nor,

MCF12A

in-vitro,

BC,

MCF7

TumCCA↑, selectivity↑, 6IL↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

6IL↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1, selectivity↑, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: 6IL, 6-Iodolactone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells