P-gp Cancer Research Results

P-gp, permeability-glycoprotein: Click to Expand ⟱
Source:
Type:
P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), is a membrane protein that plays a crucial role in the transport of various substances across cellular membranes. It is part of the ATP-binding cassette (ABC) transporter family.
P-glycoprotein is often overexpressed in a variety of cancers, including breast cancer, lung cancer, leukemia, and ovarian cancer.

- The overexpression of P-glycoprotein (P-gp), is widely considered as an important reason for the MDR (multidrug resistance).
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5442- AG,  Ome,    Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats
- in-vivo, Nor, NA
*other?, *P-gp↑, *CYP3A4↑,
5641- BCA,    Effects of the flavonoids biochanin A, morin, phloretin, and silymarin on P-glycoprotein-mediated transport
- in-vitro, Nor, NA
P-gp↑,
5675- Bos,    Modulation of Pgp function by boswellic acids
- in-vitro, Nor, NA
*P-gp↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Barriers & Transport ⓘ

P-gp↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

CYP3A4↑, 1,  

Transcription & Epigenetics ⓘ

other?, 1,  

Barriers & Transport ⓘ

P-gp↑, 2,  
Total Targets: 3

Scientific Paper Hit Count for: P-gp, permeability-glycoprotein
1 Astragalus
1 Omeprazole
1 Biochanin A
1 Boswellia (frankincense)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:232  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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