PDH Cancer Research Results

PDH, mitochondrial pyruvate dehydrogenase (PDH): Click to Expand ⟱
Source:
Type:
-An enzyme complex that plays a crucial role in cellular metabolism, particularly in the conversion of pyruvate to acetyl-CoA, which is then used to produce energy in the form of ATP. -Key enzyme in cellular metabolism that catalyzes the conversion of pyruvate (produced during glycolysis) into acetyl-CoA, which then enters the tricarboxylic acid (TCA) cycle in the mitochondria.
The phosphorylation state of PDH (p-PDH) broadly exists in the cancer cells.
Some cancer cells have been found to inhibit PDH activity, which can lead to increased lactate production and a shift towards glycolysis, even in the presence of oxygen. This is known as the Warburg effect.
-In cancer cells, PDH has been shown to be inhibited.
PDH expression is regulated by various transcription factors, including HIF-1α, c-Myc, and p53.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
1864- DCA,  MET,    Dichloroacetate Enhances Apoptotic Cell Death via Oxidative Damage and Attenuates Lactate Production in Metformin-Treated Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, T47D - in-vitro, Nor, MCF10
PDKs↓, eff↑, ROS↑, PDK1↓, lactateProd↓, p‑PDH↑, Dose∅, OCR↑, DNA-PK↑, γH2AX↑, cl‑PARP↑, selectivity↑, *toxicity∅,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE/CCNE↑, cycA1/CCNA1↑, TumCCA↑, cycD1/CCND1↑, OXPHOS↑,
3140- VitC,    Vitamin-C-dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest
- in-vitro, PC, MIA PaCa-2 - in-vitro, Nor, HEK293
citrate↓, FASN↓, ACLY↓, LDH↓, Glycolysis↓, Warburg↓, PDK1↓, GLUT1↓, LDHA↓, ECAR↓, PDH↑, eff↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   OCR↑, 2,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   citrate↓, 1,   ECAR↓, 2,   FASN↓, 1,   Glycolysis↓, 2,   lactateProd↓, 2,   LDH↓, 1,   LDHA↓, 1,   PDH↑, 2,   p‑PDH↑, 1,   PDK1↓, 2,   PDKs↓, 1,   PPP↓, 1,   Warburg↓, 1,  

DNA Damage & Repair ⓘ

DNA-PK↑, 1,   cl‑PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

cycA1/CCNA1↑, 1,   cycD1/CCND1↑, 1,   cycE/CCNE↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Migration ⓘ

Ca+2↝, 1,   TumCP↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,   eff↑, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

LDH↓, 1,  
Total Targets: 33

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

ECAR∅, 1,  

Transcription & Epigenetics ⓘ

other?, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 3

Scientific Paper Hit Count for: PDH, mitochondrial pyruvate dehydrogenase (PDH)
1 Dichloroacetate
1 Metformin
1 Resveratrol
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:245  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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