GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱
Source:
Type:
Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.


Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
6477- 1,8-Cin,    Protective effect of 1, 8-cineole (eucalyptol) against lead-induced liver injury by ameliorating oxidative stress and inflammation and modulating TLR4/MyD88/NF-κB signaling
- in-vivo, Nor, NA
*MDA↓, *GSH↑, *GPx↑, *Inflam↓, *TLR4↓, *MyD88↓, *NF-kB↓, *AST↓, *ALAT↓, *hepatoP↑, *ROS↓,
7980- AAS/EEAA,    Protective Effects of Annona Atemoya Extracts on Inflammation, Oxidative Stress, and Renal Function in Cadmium-Induced Nephrotoxicity in Wistar Rats
- in-vivo, Nor, NA
*creat↓, *SOD↑, *Catalase↑, *GPx↑, *TNF-α↓, *IL6↓, *RenoP↑, *Inflam↓, *ROS↓,
1406- AgNPs,    The antioxidant effects of silver, gold, and zinc oxide nanoparticles on male mice in in vivo condition
- in-vivo, Nor, NA
*ROS↓, *GPx↑, *Catalase↑, *ROS↑,
1905- AgNPs,    Evaluation of the effect of silver and silver nanoparticles on the function of selenoproteins using an in-vitro model of the fish intestine: The cell line RTgutGC
- in-vivo, Nor, NA
*TrxR↓, *ROS∅, GPx↑,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
5365- AV,    Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications
- Review, Nor, NA - Review, IBD, NA - Review, Diabetic, NA
*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,
2749- BetA,    Anti-Inflammatory Activities of Betulinic Acid: A Review
- Review, Nor, NA
Inflam↓, *NO↓, *IL10↑, *ICAM-1↓, *VCAM-1↓, *E-sel↓, *NF-kB↓, *IKKα↓, *COX2/PTGS2↓, *PGE2↓, *IL1β↓, *IL6↓, *IL8↓, *IL12↓, *TNF-α↑, *HO-1↑, *IL10↑, *IL2↓, *IL17↓, *IFN-γ↓, *SOD↑, *GPx↑, *GSR↑, *MDA↓, *MAPK↓,
3517- Bor,  Se,    The protective effects of selenium and boron on cyclophosphamide-induced hepatic oxidative stress, inflammation, and apoptosis in rats
- in-vivo, Nor, NA
*hepatoP↑, *ALAT↓, *AST↓, *ALP↓, *NF-kB↓, *TNF-α↓, *IL1β↓, *IL6↓, *IL10↑, *SOD↑, *Catalase↑, *MDA↓, *GSH↑, *GPx↑, *antiOx↑, *NRF2↑, *Keap1↓,
7949- BuckWS,    Producing High-Quality Buckwheat Sprouts: The Combined Effects of Melatonin and UV-B Treatment
- Study, Nor, NA
*eff↑, *SOD↑, *GPx↑, *Catalase↑, *other↑,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2/PTGS2↓, *Dose↝,
5902- CAR,    A novel antagonist of TRPM2 and TRPV4 channels: Carvacrol
- in-vitro, Nor, HEK293
*other↓, *GSH↑, *GPx↑, *ROS↓, *Apoptosis↓,
6662- Cen,    Assessment report on Centella asiatica (L.) Urban, herba
- Review, Nor, NA
*cognitive↑, *Inflam↓, *AntiBio↑, *Imm↑, *antiOx↑, *Wound Healing↑, *cardioP↑, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *MDA↓, *lipid-P↓, *ROS↓, *memory↑, *GABA↑, *antiPs↑, *BioAv↝,
6010- CGA,    The Biological Activity Mechanism of Chlorogenic Acid and Its Applications in Food Industry: A Review
- Review, Nor, NA
*antiOx↑, *hepatoP↑, *RenoP↑, AntiTum↑, *glucose↝, *Inflam↓, *neuroP↑, *ROS↓, *Keap1↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *GSH↑, *MDA↓, *p‑ERK↑, *GRP78/BiP↑, *CHOP/DDIT3↑, *GRP94↑, *Casp3↓, *Casp9↓, *HGF/c-Met↑, *TNF-α↓, *TLR4↓, *MAPK↓, *IL1β↓, *iNOS↓, TCA↓, Glycolysis↓, Bcl-2↓, BAX↑, MAPK↑, JNK↑, CSCs↓, Nanog↓, SOX2↓, CD44↓, OCT4↓, P53↑, P21↑, *SOD1↑, *AGEs↓, *GLUT2↑, *HDL↑, *Fas↓, *HMG-CoA↓, *NF-kB↓, *HO-1↓, *COX2/PTGS2↓, *TLR4↓, *BioAv↑, *BioAv↝, TumCP↓, TumCMig↓, TumCI↓,
6128- CHr,    Chrysin: A Comprehensive Review of Its Pharmacological Properties and Therapeutic Potential
- Review, Nor, NA - Review, Var, NA - Review, AD, NA
*antiOx↑, *Inflam↓, AntiCan↑, *neuroP↑, *ROS↓, *BioAv↓, *BioAv↑, *cardioP↑, *COX2/PTGS2↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *lipid-P↓, *Apoptosis↓, *NRF2↑, *HO-1↑, *MDA↓, *GSH↑, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *5HT↑, *Casp3↓, *Casp9↓, TumCCA↑, MAPK↓, PI3K↓, Akt↓, TumCP↓, TET1↑, TLR4↓, HER2/EBBR2↓, HK2↓, Glycolysis↓, glucose↓, lactateProd↓, ROS↑, mTOR↓, TumAuto↑, tumCV↓, ER Stress↑, UPR↑, PERK↑, ATF4↑, eIF2α↑, BioAv↑,
6622- Cic,    Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and Extends Lifespan in Caenorhabditis elegans
- in-vivo, Nor, NA
*ROS↓, *AMPK↑, *GPx↑, *SOD↑, *SOD2↑, *PGC-1α↑, *Akt↓, *mTOR↓, *Insulin↓, *antiOx↑, *AntiAge↑,
6300- Cro,    Interaction of saffron and its constituents with Nrf2 signaling pathway: A review
- Review, Nor, NA - Review, Arthritis, NA
*antiOx↑, *Inflam↓, *AntiTum↑, *hepatoP↑, *cardioP↑, *neuroP↑, *NRF2↑, *NF-kB↓, *iNOS↓, *COX2/PTGS2↓, *IL6↓, *IL10↓, *IL1β↓, *TNF-α↓, *HO-1↑, ROS↑, NQO1↑, NRF2↑, HO-1↑, NQO2↑, LDHA↓, ATP↓, *hepatoP↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *ROS↓, *cardioP↑, *ER Stress↓, *GRP78/BiP↓, *CHOP/DDIT3↓, *Apoptosis↓, *miR-34a↓, *SIRT1↑, chemoP↑,
7423- CS,    Prophylactic effects of Cynara scolymus L. leaf and flower hydroethanolic extracts against diethylnitrosamine/acetylaminoflourene-induced lung cancer in Wistar rats
- in-vivo, Nor, NA
*lipid-P↓, *GSTs↑, *GPx↑, *GSR↑, *SOD↑, *P53↑, *Bcl-2↑, *ROS↓,
7429- CS,    Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
- Review, Nor, NA - Review, IBD, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *hepatoP↑, *lipid-P↓, *TNF-α↓, *ICAM-1↓, *IL1β↓, *IL6↓, *MUC1↑, *OCLN↑, *IBI↑, *ROS↓, *cardioP↑, *SOD↑, *GPx↑, *GSH↑, *TG/TAG↓, *LDL↓, *neuroP↑, *5HT↑, *BDNF↑,
6283- DL,    D-limonene inhibits peritoneal adhesion formation in rats via anti-inflammatory, anti-angiogenic, and antioxidative effects
- in-vivo, Nor, NA
*TGF-β1↓, *VEGF↓, *MDA↓, *GPx↑, *Catalase↑, *Inflam↓, *ROS↓, *angioG↓,
3222- EGCG,    Epigallocatechin gallate and mitochondria—A story of life and death
- Review, Nor, NA
*lipid-P↓, *SOD↑, *Catalase↑, GPx↑, *GR↑, *GSTs↑, *GSH↑, *SIRT1↑, *PGC1A↑, *other↑,
6784- EGCG,    Dietary (−)-Epigallocatechin Gallate (EGCG): State-of-the-Art Advances in Bioactivities, Bioavailability Enhancement Strategies, and Applications in Nutrition and Health
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *cardioP↑, *neuroP↑, *GutMicro↑, *AntiBio↑, *ROS↓, *TNF-α↓, *IL6↓, TumCP↓, *LDL↓, *NO↓, *Obesity↓, *p‑tau↓, *Aβ↓, *NRF2↑, *SOD↑, *Catalase↑, *GPx↑, *NLRP3↓, *mTOR↓, TumCCA↑, NRF2↓, Apoptosis↑, SIRT1↓, miR-25-5p↓, PARP↑, Casp3↑, Casp9↑, ER Stress↑, TumAuto↑, EMT↓, TumCI↓, TumCMig↓, TGF-β↓, Smad1↓, STAT3↓, VEGF↓, angioG↓, Imm↑, EGFR↓, *GutMicro↑, *Bacteria↓, *AntiViral↑, *BioAv↓, *BioAv↑, *eff↑, *BioAv↑, eff↑, ChemoSen↑, *toxicity↝,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6871- FA,  Sesame,    Nano-encapsulated ferulic acid in sesame protein isolate alleviates acrylamide-induced liver toxicity and genotoxicity in rats via oxidative stress and DNA damage modulation
- in-vivo, Nor, NA
*GSH↑, *GPx↑, *SOD↓, *Catalase↑, *MDA↓, *IL6↓, *TNF-α↑, *DNAdam↓, *hepatoP↑, *BioAv↓, *BioAv↑,
6877- FA,    The protective role of ferulic acid on sepsis-induced oxidative damage in Wistar albino rats
- in-vivo, Nor, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *hepatoP↑, *DNAdam↓, *Sepsis↓, *MDA↓, *GSH↑, *GPx↑, *ROS↓,
6885- FA,    Mitigation of renal toxicity induced by paraquat using ferulic acid: Role of inflammatory pathways
- in-vivo, Nor, NA
*Dose↝, *TAC↑, *MDA↓, *RenoP↑, *PI3K↓, *Akt↓, *ROS↓, *Inflam↓, PPARγ↝, *NF-kB↓, *IL6↓, *TNF-α↓, *iNOS↓, *ALAT↓, *AST↓, *Urea↓, *Catalase↑, *SOD↑, *GPx↑, *GSH↑,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2/PTGS2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27/CDKN1B↑, P53↑, VEGF↓, MAPK↓,
7562- HYP,  doxoR,    Hyperoside Inhibits Doxorubicin-Induced Ferroptosis in Cardiomyocytes via the Nrf2/GPX4 Pathway
- in-vivo, Nor, NA
*ROS↓, *Ferroptosis↓, *Apoptosis↓, *cardioP↑, *MDA↓, *SOD↑, *GPx↑, *i-Iron↓, *4-HNE↓, *GSH↑, *Ferritin↑, *ACSL4↓, *NRF2↑, *GPx4↑,
7546- HYP,    Hyperoside attenuates hydrogen peroxide-induced L02 cell damage via MAPK-dependent Keap₁-Nrf₂-ARE signaling pathway
- in-vitro, Nor, L02
*TAC↑, *GPx↑, *Catalase↑, *ROS↓, *MMP↓, *LDH↑, *HO-1↑, *NRF2↑,
7881- isoO,    Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice
- in-vivo, Nor, NA
*Weight↑, *toxicity↓, *GutMicro↑, *SOD↑, *GPx↑, *MDA↓, *Inflam↓,
2907- LT,    Protective effect of luteolin against oxidative stress‑mediated cell injury via enhancing antioxidant systems
- in-vitro, Nor, NA
*ROS↓, *Casp9↓, *Casp3↓, *Bcl-2↑, *BAX↓, *GSH↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *antiOx↑, *lipid-P↓, *p‑γH2AX↓, eff↑,
3531- Lyco,    Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system
- in-vivo, Nor, NA
*NRF2↑, *HO-1↑, *NQO1↑, *ROS↓, *mtDam↓, *Bcl-2↑, *BAX↓, *Casp9↓, *Casp3↓, *Apoptosis↓, *RenoP↑, *lipid-P↓, *SOD↑, *GPx↑, *Inflam↓, *TNF-α↓, *IL6↓, *IL10↓,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2/PTGS2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
6419- MEL,    The potential influence of melatonin on mitochondrial quality control: a review
- Review, Nor, NA
*mt-ACC⇅, *PKM1↑, *PKM2↑, *Glycolysis↝, *PDKs↑, *FAO↑, *ETC↑, *OXPHOS↑, *ATP↑, Glycolysis↓, OXPHOS↑, *Ca+2↓, *ROS↓, *antiOx↑, *SOD2↑, *GPx↑, *Catalase↑, *MFN1↑, *MFN2↑, *OPA1↑, *YAP/TEAD↑, *Hippo↑, *SIRT1↑, *PGC-1α↑, *DRP1/DNM1L↓,
3462- MF,    The Effect of a Static Magnetic Field on microRNA in Relation to the Regulation of the Nrf2 Signaling Pathway in a Fibroblast Cell Line That Had Been Treated with Fluoride Ions
- in-vitro, Nor, NA
*NRF2↑, *Keap1↓, *SOD↑, *GPx↑, *ROS↓, *MDA↓, *SOD1↑, *SOD2↑, *GSR↑,
3484- MF,    Extremely low frequency pulsed electromagnetic fields cause antioxidative defense mechanisms in human osteoblasts via induction of •O2 − and H2O2
- in-vitro, Nor, NA
*GPx↑, *SOD2↑, *Catalase↑, *GSR↑, *ROS↓,
2311- MFrot,  MF,    Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials
- in-vivo, Nor, HaCaT
*COX2/PTGS2↓, *Inflam↓, *MMP9↑, *GPx↑, *Diff↑,
1683- PBG,  Rad,    Protective effect of propolis in protecting against radiation-induced oxidative stress in the liver as a distant organ
- in-vivo, Nor, NA
GPx↑, SOD↓, RadioS↑,
3596- PI,    Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress
- in-vivo, Nor, NA
*TBARS↑, *SOD↑, *Catalase↑, *GSTs↑, *GPx↑, *GSH↑, *ROS↓,
5025- QC,    New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation
- Review, Nor, NA
*antiOx↑, *Inflam↓, *NRF2↓, *ROS↓, *cardioP↑, *HO-1↑, *Catalase↑, *GPx↑, *NQO1↑, *SIRT1↑,
2343- QC,    Pharmacological Activity of Quercetin: An Updated Review
- Review, Nor, NA
*ROS↓, *GSH↑, *Catalase↑, *SOD↑, *MDA↓, *GPx↑, *Copper↓, *Iron↓, Apoptosis↓, TumCCA↑, MMP2↓, MMP9↓, GlucoseCon↓, lactateProd↓, PKM2↓, GLUT1↓, LDHA↓, ROS↑,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3062- RES,    Resveratrol enhances post-injury muscle regeneration by regulating antioxidant and mitochondrial biogenesis
- in-vivo, Nor, NA
*antiOx↑, *Keap1↓, *NRF2↑, *HO-1↑, *GPx↑, *SOD↑,
3026- RosA,    Modulatory Effect of Rosmarinic Acid on H2O2-Induced Adaptive Glycolytic Response in Dermal Fibroblasts
- in-vitro, Nor, NA
*ROS↓, *ATP↑, *NADPH↓, *HK2↓, *PFK2↓, *LDHA↓, *GSR↑, *GPx↑, *Prx↑, *Trx↑, *antiOx↑, *GSH↑, *ROS↓, *GlucoseCon↓, *lactateProd↓, *Glycolysis↝, *ATP↑, *NADPH↓, *PPP↓,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑,
4615- Se,  Rad,    Selenium as an adjuvant for modification of radiation response
- Review, Nor, NA
*antiOx↑, *radioP↑, *GSH↑, *GPx↑, *Dose↝, selectivity↑, RadioS↑,
4488- Se,  Chit,  PEG,    Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats
- in-vivo, Liver, HepG2 - in-vivo, Nor, HL7702
tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,
6047- SeNPs,  CGA,    Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis
- in-vitro, Nor, NA
*Dose↝, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *MAPK↝, *PI3K↝,
4612- SeNPs,  Rad,    Histopathological Evaluation of Radioprotective Effects: Selenium Nanoparticles Protect Lung Tissue from Radiation Damage
- in-vivo, Nor, NA
*radioP↑, *Inflam↓, *antiOx↑, *Dose↝, *DNAdam↓, *ROS↓, *SOD↑, *GPx↑, *Dose↝, *eff↑,
4441- SeNPs,    The Role of Selenium Nanoparticles in the Treatment of Liver Pathologies of Various Natures
- Review, Nor, NA
*ROS↓, *hepatoP↑, *selenoP↑, *ALAT↓, *AST↓, *GSH↑, *GPx↑, *TNF-α↓, *IL6↓, *NF-kB↓, *p65↓, *Dose⇅,

Showing Research Papers: 1 to 50 of 63
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 63

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 4,   GSH↑, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 2,   OXPHOS↑, 1,   ROS↑, 6,   SOD↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   glucose↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 4,   HK2↓, 1,   lactateProd↓, 2,   LDH↓, 1,   LDHA↓, 2,   PKM2↓, 1,   PPARγ↝, 1,   SIRT1↓, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 3,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 3,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 2,   Fas↑, 1,   JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   p27/CDKN1B↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   miR-25-5p↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   ER Stress↑, 3,   NQO2↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 2,   P53↑, 2,   PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   Cyc↓, 1,   P21↑, 2,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 2,   EMT↓, 2,   miR-34a↓, 1,   mTOR↓, 1,   Nanog↓, 1,   NOTCH1↓, 1,   OCT4↓, 1,   PI3K↓, 1,   SOX2↓, 1,   STAT3↓, 2,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ki-67↓, 1,   MMP2↓, 1,   MMP9↓, 1,   MMPs↓, 1,   Slug↓, 1,   Smad1↓, 1,   TET1↑, 1,   TGF-β↓, 1,   TRIB3↑, 1,   TumCI↓, 4,   TumCMig↓, 2,   TumCP↓, 3,   TumMeta↓, 1,   TumMeta↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   ATF4↑, 1,   EGFR↓, 1,   VEGF↓, 3,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Imm↑, 1,   Inflam↓, 2,   NF-kB↓, 1,   NF-kB↑, 1,   NK cell↑, 1,   TLR4↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   ChemoSen↑, 3,   eff↑, 4,   RadioS↑, 3,   selectivity↑, 4,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   EGFR↓, 1,   HER2/EBBR2↓, 1,   Ki-67↓, 1,   LDH↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 2,   AntiTum↑, 2,   cardioP↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,  
Total Targets: 117

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↓, 1,   antiOx↑, 23,   Catalase↓, 1,   Catalase↑, 24,   Copper↓, 1,   Ferroptosis↓, 1,   GPx↑, 46,   GPx4↑, 1,   GSH↑, 24,   GSR↑, 8,   GSTs↓, 1,   GSTs↑, 4,   H2O2↓, 2,   HDL↑, 2,   HO-1↓, 1,   HO-1↑, 10,   Iron↓, 1,   i-Iron↓, 1,   Keap1↓, 4,   lipid-P↓, 11,   MDA↓, 18,   MFN1↑, 1,   MFN2↑, 1,   MPO↓, 1,   NQO1↑, 2,   NRF2↓, 1,   NRF2↑, 13,   OPA1↑, 1,   OXPHOS↑, 1,   Prx↑, 1,   ROS↓, 37,   ROS↑, 1,   ROS∅, 1,   selenoP↑, 1,   SOD↓, 1,   SOD↑, 32,   SOD1↑, 2,   SOD2↑, 4,   TAC↑, 5,   TBARS↑, 1,   Thiols↑, 1,   Trx↑, 1,   TrxR↓, 1,   VitC↑, 2,   VitE↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ATP↑, 3,   DRP1/DNM1L↓, 1,   ETC↑, 1,   Insulin↓, 1,   MMP↓, 1,   MMP↑, 1,   mtDam↓, 1,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

mt-ACC⇅, 1,   ACSL4↓, 1,   ALAT↓, 6,   AMPK↓, 1,   AMPK↑, 2,   BUN↓, 1,   FAO↑, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GLUT2↑, 1,   GlutMet↑, 1,   Glycolysis↝, 2,   HK2↓, 1,   HMG-CoA↓, 2,   lactateProd↓, 1,   LDH↑, 1,   LDHA↓, 1,   LDL↓, 3,   NAD↓, 1,   NADPH↓, 2,   PDKs↑, 1,   PFK2↓, 1,   PGC1A↑, 1,   PKM1↑, 1,   PKM2↓, 1,   PKM2↑, 1,   PPP↓, 1,   SIRT1↑, 5,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Apoptosis↓, 6,   BAX↓, 4,   Bcl-2↓, 1,   Bcl-2↑, 3,   Casp3↓, 6,   Casp9↓, 5,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   GADD34↓, 1,   HGF/c-Met↑, 1,   Hippo↑, 1,   iNOS↓, 4,   MAPK↓, 3,   MAPK↝, 1,   YAP/TEAD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 2,   other↑, 4,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   GRP78/BiP↑, 1,   GRP94↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 4,   P53↓, 1,   P53↑, 1,   p‑γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↑, 1,   p‑ERK↑, 1,   GSK‐3β↑, 1,   miR-34a↓, 1,   mTOR↓, 2,   PI3K↓, 1,   PI3K↝, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,   Ca+2↓, 1,   E-sel↓, 1,   MMP3↓, 1,   MMP9↓, 1,   MMP9↑, 1,   MUC1↑, 1,   TGF-β1↓, 1,   TGF-β1↑, 1,   VCAM-1↓, 1,   Vim↓, 1,   ZO-1↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↓, 1,   Hif1a↓, 1,   NO↓, 5,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   GastroP↑, 1,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 10,   CRP↓, 1,   ICAM-1↓, 2,   IFN-γ↓, 2,   IKKα↓, 1,   IL10↓, 3,   IL10↑, 5,   IL12↓, 1,   IL17↓, 2,   IL1β↓, 8,   IL2↓, 1,   IL6↓, 13,   IL8↓, 1,   Imm↓, 1,   Imm↑, 2,   Inflam↓, 22,   MyD88↓, 1,   NF-kB↓, 12,   p65↓, 1,   PGE2↓, 3,   TLR4↓, 3,   TNF-α↓, 13,   TNF-α↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 2,   BDNF↓, 1,   BDNF↑, 1,   GABA↑, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 8,   BioAv↝, 3,   Dose⇅, 1,   Dose↝, 7,   eff↑, 3,   Half-Life↓, 1,   Half-Life↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 6,   ALP↓, 2,   AST↓, 6,   creat↓, 2,   CRP↓, 1,   Ferritin↑, 1,   GutMicro↑, 4,   IL6↓, 13,   LDH↑, 1,   TG/TAG↓, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 3,   AntiDiabetic↑, 4,   antiPs↑, 1,   AntiTum↑, 1,   cardioP↑, 11,   cognitive↑, 2,   hepatoP↑, 12,   memory↑, 3,   neuroP↑, 12,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   radioP↑, 2,   RenoP↑, 5,   toxicity↓, 2,   toxicity↝, 2,   toxicity∅, 1,   Weight↑, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 2,   Sepsis↓, 1,  
Total Targets: 220

Scientific Paper Hit Count for: GPx, Glutathione peroxidases
4 Selenium NanoParticles
4 Thymoquinone
3 Selenium
3 Ferulic acid
3 Magnetic Fields
3 Radiotherapy/Radiation
2 Silver-NanoParticles
2 Carvacrol
2 Chlorogenic acid
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 EGCG (Epigallocatechin Gallate)
2 Hyperoside
2 Lycopene
2 Quercetin
2 Resveratrol
2 Rosmarinic acid
2 chitosan
2 Silymarin (Milk Thistle) silibinin
2 Selenite (Sodium)
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Annona atemoya Seed Extract
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Apigenin (mainly Parsley)
1 Aloe anthraquinones
1 Betulinic acid
1 Boron
1 buckwheat sprouts
1 Centella asiatica / Gotu kola → asiaticoside
1 Chrysin
1 Cichoric acid / Chicoric acid
1 Crocetin
1 D-limonene
1 Emodin
1 Sesame seeds and Oil
1 Hydroxycinnamic-acid
1 doxorubicin
1 isoorientin
1 Luteolin
1 Melatonin
1 Magnetic Field Rotating
1 Propolis -bee glue
1 Piperine
1 polyethylene glycol
1 Sulforaphane (mainly Broccoli)
1 5-fluorouracil
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:418  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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