COL2A1 Cancer Research Results

COL2A1, COL2A1: Click to Expand ⟱
Source:
Type: gene
The COL2A1 gene is a gene that encodes for the pro-alpha1(II) chain of type II collagen, a protein that is a major component of cartilage. While the primary function of COL2A1 is related to cartilage development and maintenance, research has also explored its potential role in cancer. Overexpressed in: Osteosarcoma, chondrosarcoma, breast, lung.
COL2A1 may facilitate the migration and invasion of tumor cells by interacting with other proteins and promoting the degradation of the extracellular matrix.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3535- MFrot,  MF,    Pulsed Electromagnetic Field Stimulation in Osteogenesis and Chondrogenesis: Signaling Pathways and Therapeutic Implications
- Review, Nor, NA
*eff↑, *COL2A1↑, *SOX9↑, *Ca+2↑, *FAK↑, *F-actin↑, *Inflam↓, *other↑, *Diff↑, *BMD↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Kinase & Signal Transduction ⓘ

SOX9↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,  

Migration ⓘ

Ca+2↑, 1,   COL2A1↑, 1,   F-actin↑, 1,   FAK↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: COL2A1, COL2A1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:422  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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