Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱

Source: CGL-Driver Genes

Type: TSG

Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

7407-

Amla,

Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review

Review,

Nor,

*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

in-vitro,

PC,

AsPC-1

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

in-vivo,

NA,

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

2024-

Bos,

Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro

in-vitro,

BC,

MCF7

 101.1

in-vitro,

Nor,

MCF10

275.2

MMP↓, Cyt‑c↑, ROS↑, Casp8↑, Casp9↑, AntiTum↑, selectivity↑, TumCCA↑,

7159-

CHA,

ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin

vitro+vivo,

GC,

HGC27

in-vitro,

GC,

AGS

in-vitro,

GC,

BGC-823

in-vitro,

GC,

SGC-7901

in-vitro,

Nor,

HEK293

TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,

6318-

DRE,

Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways

vitro+vivo,

CRC,

HCT116

mouse xenograft model of colon cancer

NA,

Nor,

NCM460

TumCD↑, Apoptosis↑, Casp8↑, selectivity↑, TumCMig↓, selectivity↑, Dose↝, toxicity↓, TumCG↓, MMP↓, mt-ROS↑, *ROS↓, BID↑, Bcl-2↓, PARP↓, NF-kB↑, *NF-kB↓, Casp1↑, *Casp1↓, COX2/PTGS2↑, OXPHOS↓, ETC↓,

1332-

EMD,

Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway

in-vivo,

Nor,

HepaRG

rata

*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,

1318-

EMD,

Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species

in-vitro,

Nor,

HL7702

*TumCCA↑, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↓, *Bax:Bcl2↑, *cl‑Casp3↑, *cl‑Casp8↑, *cl‑Casp9↑, *cl‑PARP↑,

2841-

FIS,

Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer

in-vitro,

Nor,

RAW264.7

LPS-induced Raw264.7 cells

in-vitro,

Liver,

HepG2

10, 25, 100, and 200 μM, 24 h

in-vitro,

Liver,

Hep3B

in-vitro,

Liver,

HUH7

*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP/DDIT3↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,

7020-

Fuc,

Systematic synthesis of low-molecular weight fucoidan derivatives and their effect on cancer cells

in-vitro,

BC,

MCF7

in-vitro,

Cerv,

HeLa

in-vitro,

Nor,

WI38

tumCV↓, selectivity↑, Apoptosis↑, Casp8↑, Casp9↑,

823-

GAR,

Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins

in-vitro,

BC,

MCF7

in-vitro,

Nor,

MCF10

in-vitro,

CRC,

HCT116

Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,

6573-

Ger,

Systematic elucidation of the mechanism of geraniol via network pharmacology

Study,

Nor,

Study,

Var,

HO-1↝, HRAS↓, *IL8↓, *AChE↓, NF-kB↓, PCNA↓, BAX↑, Bcl-2↓, P53↑, Casp3↑, Casp8↑, Casp9↑,

843-

Gra,

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling

in-vitro,

NMSC,

A431

3.5 µg/mL

DCM fraction proved to be by far the most potent in inhibiting the proliferation

in-vitro,

NMSC,

UW-BCC1

4.0 µg/mL

in-vitro,

Nor,

NHEKn

38.8 µg/mL

10-fold higher than in noncancerous NHEKn cells

TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,

7560-

HYP,

Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity

Review,

Nor,

Review,

AD,

*RenoP↓, Casp3↑, Casp8↑, MDA↑, GSH↓, SOD↓, Catalase↓, VEGF↓, Bcl-2↓, TumCG↓, p‑Akt↓, PI3K↓, TumCCA↑, TumCP↓, BMP7/OP1↓, *ZO-1↑, *BBB↝, *p‑Akt↑, *GSK‐3β↑, *SOD↑, *Catalase↑, *GSH↑, *SIRT1↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL8↓, *TNF-α↓, *ROS↓, *MDA↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BDNF↑, *TrkB↑, *NGF↑, *Apoptosis↓, *cardioP↑, *AST↓, *hepatoP↑, *AST↓, *ALAT↓, *MDA↓, *BACH1↓, *neuroP↑, *Stroke↓, *ICAM-1↓, *VCAM-1↓, *TLR4↓, *COX2/PTGS2↓, *RenoP↑, *NLRP3↓, *Casp1↓, *ASC↓, *BioAv↓, *BioAv↑, *toxicity↓,

2921-

LT,

Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies

Review,

Nor,

*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,

2046-

PB,

Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment

in-vitro,

BC,

MCF7

0.1–20 mM) for 24, 48, 72 h

in-vitro,

BC,

MDA-MB-468

in-vitro,

Nor,

MCF10

Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,

7951-

RT,

BuckWS,

The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

Review,

Nor,

*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,

3416-

TQ,

Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway

in-vitro,

Bladder,

T24/HTB-9

 TQ (20–100 μM) for 24 h

in-vitro,

Bladder,

253J

in-vitro,

Nor,

SV-HUC-1

TumCP↓, Apoptosis↑, ER Stress↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp7↑, cl‑PARP↑, Cyt‑c↑, PERK↑, IRE1↑, ATF6↑, p‑eIF2α↑, ATF4↑, GRP78/BiP↑, CHOP/DDIT3↑,

Showing Research Papers: 1 to 17 of 17

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1, Stroke↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2, Catalase↑, 2, GPx↑, 1, GSH↑, 3, HDL↑, 1, HO-1↑, 1, lipid-P↓, 1, MDA↓, 5, NQO1↑, 1, NRF2↑, 1, ROS↓, 5, ROS↑, 2, ROS∅, 1, SOD↑, 3,

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 2,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2, AMPK↑, 1, HMG-CoA↓, 1, LDL↓, 1, PPARα↑, 1, SIRT1↑, 2, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1, Apoptosis↓, 1, BAX↓, 2, Bax:Bcl2↑, 2, Bcl-2↑, 1, Casp1↓, 3, Casp3↓, 2, Casp3↑, 1, cl‑Casp3↑, 1, Casp8↑, 1, cl‑Casp8↑, 1, Casp9↓, 1, Casp9↑, 1, cl‑Casp9↑, 1, Fas↑, 2, iNOS↓, 1, JNK↓, 1, MAPK↓, 1, p38↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, ER Stress↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1, P53↑, 2, cl‑PARP↑, 2,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, P21↓, 1, P21↑, 2, TumCCA↑, 2,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↑, 1,

Migration(tgid=13) ⓘ

BACH1↓, 1, TXNIP↓, 1, VCAM-1↓, 1, ZO-1↑, 2,

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↝, 1, GastroP↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1, COX1↓, 1, COX2/PTGS2↓, 3, CRP↓, 1, ICAM-1↓, 1, IFN-γ↓, 1, IL18↓, 1, IL1β↓, 3, IL2↓, 1, IL6↓, 3, IL8↓, 2, Inflam↓, 3, NF-kB↓, 2, TLR4↓, 2, TNF-α↓, 3,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1, BDNF↑, 1, NGF↑, 1, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 5, BioAv↑, 1, BioAv↝, 1, Dose↝, 2, eff↓, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2, AST↓, 3, CRP↓, 1, GutMicro↑, 1, IL6↓, 3, TG/TAG↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1, cardioP↑, 2, chemoP↑, 1, hepatoP↑, 3, neuroP↑, 2, radioP↑, 1, RenoP↓, 1, RenoP↑, 1, toxicity↓, 4,
Total Targets: 103

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase

2 Emodin
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Apigenin (mainly Parsley)
1 Metformin
1 Boswellia (frankincense)
1 chaetocin
1 Dandelion Root
1 Fisetin
1 Fucoidan
1 Garcinol
1 Geraniol
1 Graviola
1 Hyperoside
1 Luteolin
1 Phenylbutyrate
1 Rutin
1 buckwheat sprouts
1 Thymoquinone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:44  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

Casp8 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

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