Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
Source:
Type:
The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3442- ALA,    α‑lipoic acid modulates prostate cancer cell growth and bone cell differentiation
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, C4-2B - in-vitro, Nor, 3T3
tumCV↓, TumCMig↓, TumCI↓, ROS↑, Hif1a↑, JNK↑, Casp↑, TumCCA↑, Apoptosis↑, selectivity↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF-7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
2046- PB,    Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-468 - in-vitro, Nor, MCF10
Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,
5183- PEITC,  Cisplatin,    Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Nor, HaCaT
DNAdam↑, Apoptosis↑, ChemoSen↑, ROS↑, mt-ROS↑, Casp↑, Casp3↑, selectivity↑, TumCP↓, tumCV↓, eff↓,
1733- SFN,    Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
- in-vitro, PC, PanCSC - in-vitro, Nor, HPNE - in-vitro, Nor, HNPSC
CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2010- SK,    Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
- in-vitro, Lung, H1975 - in-vitro, Lung, H1650 - in-vitro, Nor, CCD19
EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,
3142- VitC,    Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Nor, MCF12A
TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1↓, BNIP3↓,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH/GSSG↓, 1,   lipid-P↑, 1,   NADH↓, 1,   ROS↑, 6,   i-ROS?, 1,   mt-ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP?, 1,   MMP↓, 4,   MPT↑, 1,  

Core Metabolism/Glycolysis ⓘ

HK2↓, 1,   LDH↑, 1,   PDK1↓, 2,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 9,   BAX↑, 2,   Bcl-2↓, 3,   Casp↑, 11,   Casp3↑, 4,   Casp7↑, 1,   Casp8↑, 1,   Casp9↑, 1,   Cyt‑c↑, 4,   Endon↑, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   p38↑, 1,   TRAIL↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics ⓘ

tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   p‑eIF2α↓, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   IRE1↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes ⓘ

BNIP3↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 3,   DNArepair↓, 1,   P53↑, 1,   PARP↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   Diff↓, 1,   Gli↓, 1,   Gli1↓, 1,   HDAC↓, 1,   mTOR⇅, 1,   Nanog↓, 1,   OCT4↓, 1,   PDGFRA↓, 1,   PI3K↓, 1,   PTEN↑, 1,   Shh↓, 1,   Smo↓, 1,   STAT↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 1,  

Migration ⓘ

Ca+2↑, 1,   GLI2↓, 1,   TRIB3↑, 1,   TSC1↑, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hif1a↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   Dose↝, 1,   Dose∅, 1,   eff↓, 4,   eff↑, 3,   selectivity↑, 9,   TET2↑, 1,  

Clinical Biomarkers ⓘ

E6↓, 1,   E7↓, 1,   EGFR↓, 1,   LDH↑, 1,   TRIB3↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   Obesity↓, 1,   TumW↓, 1,   Weight↑, 1,  
Total Targets: 91

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ROS↓, 1,   ROS∅, 1,  

Cell Death ⓘ

TRPV1↑, 1,  

Migration ⓘ

Ca+2↑, 1,  

Barriers & Transport ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   BioEnh↑, 1,   Half-Life↓, 1,   Half-Life∅, 1,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 19

Scientific Paper Hit Count for: Casp, caspase
2 Shikonin
1 Alpha-Lipoic-Acid
1 Capsaicin
1 Carvacrol
1 Ellagic acid
1 Emodin
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Cisplatin
1 Sulforaphane (mainly Broccoli)
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:443  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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