Casp Cancer Research Results

Casp, caspase: Click to Expand ⟱
Source:
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The caspase family of proteases are essential to initiate and execute apoptotic cell death. Targeting caspase pathways by gene therapy or endogenous inhibitors represents a promising therapeutic strategy for cancer.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspases are a cysteine protease that speed up a chemical reaction via pointing their target substrates following an aspartic acid residue.1 They are grouped into apoptotic (caspase-2, 3, 6, 7, 8, 9 and 10) and inflammatory (caspase-1, 4, 5, 11 and 12) mediated caspases.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3442- ALA,    α‑lipoic acid modulates prostate cancer cell growth and bone cell differentiation
- in-vitro, Pca, 22Rv1 - in-vitro, Pca, C4-2B - in-vitro, Nor, 3T3
tumCV↓, TumCMig↓, TumCI↓, ROS↑, Hif1a↑, JNK↑, Casp↑, TumCCA↑, Apoptosis↑, selectivity↑,
5858- CAP,    Capsaicin as a Microbiome Modulator: Metabolic Interactions and Implications for Host Health
- Review, Nor, NA - Review, AD, NA
*BBB↓, *GutMicro↑, Obesity↓, *Inflam↓, *AntiCan↑, *TRPV1↑, *Ca+2↑, *antiOx↑, *cardioP↑, *BioAv↓, *Half-Life↓, *BioAv↝, *BioAv↑, *neuroP↑, Apoptosis↑, p38↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, TRIB3↑, NADH↓, SIRT1↓, TumCG↓, TumCMig↓, TOP1↓, TOP2↓, β-catenin/ZEB1↓, *ROS↓, *Aβ↓,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP/DDIT3↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
7172- CHA,    Chaetocin enhances tumor necrosis factor‑related apoptosis‑inducing ligand‑mediated apoptosis by enhancing DR5 stabilization and reactive oxygen species generation in human glioblastoma cells
- NA, GBM, U343 - NA, GBM, U87MG - NA, GBM, U251 - NA, GBM, T98G - NA, Nor, HEK293
Casp↑, Apoptosis↑, selectivity↑, DR5↑, ROS↑,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
6277- DL,  docx,    d-Limonene sensitizes docetaxel-induced cytotoxicity in human prostate cancer cells: Generation of reactive oxygen species and induction of apoptosis
- in-vitro, Pca, DU145 - in-vitro, Nor, PZ-HPV-7
ChemoSen↑, selectivity↑, ROS↑, GSH↓, Casp↑, eff↓, TumCP↓, cl‑Casp9↑, cl‑Casp3↑, P21↑, BAD↑, cl‑PARP↑, Bcl-xL↓, P53↑, mtDam↑, *toxicity↓,
1608- EA,    Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity
- in-vitro, Cerv, HeLa - in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, Lung, A549 - in-vitro, Nor, HUVECs
eff↑, Dose∅, *BioAv↑, selectivity↑, TumCP↓, Casp↑, PTEN↑, TSC1↑, mTOR⇅, Akt↓, PDK1 / PDPK1↓, E6↓, E7↓, DNAdam↑, ROS↑, *BioAv↓, *BioEnh↑, *Half-Life∅,
5223- EMD,    Emodin inhibits colon cancer by altering BCL-2 family proteins and cell survival pathways
- in-vitro, CRC, DLD1 - in-vitro, Nor, CCD841
tumCV↓, Apoptosis↑, selectivity↑, Casp↑, Bcl-2↓, MMP↓, TumCD↑, MAPK↓, JNK↓, PI3K↓, Akt↓, NF-kB↓, STAT↓, Diff↓, P53↑, PARP↓,
7542- HT,    Hydroxytyrosol Induces Apoptosis and Cell Cycle Arrest and Suppresses Multiple Oncogenic Signaling Pathways in Prostate Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, C4-2B - in-vitro, Nor, RWPE-1
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK2↓, CDK4↓, Apoptosis↑, Casp↑, cl‑PARP↑, Bax:Bcl2↑, tumCV↓, Akt↓, STAT3↓, NF-kB↓, AR↓, ROS↑, mtDam↑, BioAv↓, toxicity↓, eff↑,
7689- iod,    Uptake and antitumoral effects of iodine and 6-iodolactone in differentiated and undifferentiated human prostate cancer cell lines
- in-vitro, Nor, RWPE-1 - in-vitro, Pca, LNCaP - vitro+vivo, Pca, DU145
Bax:Bcl2↑, Casp↑, TumCG↓,
2046- PB,    Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-468 - in-vitro, Nor, MCF10
Apoptosis↑, i-ROS?, Casp↑, MMP?, selectivity↑, *ROS∅, HDAC↓, DNArepair↓, Casp3↑, Casp8↑, *toxicity↓, TumCCA↑,
5183- PEITC,  Cisplatin,    Phenethyl Isothiocyanate Induces Apoptosis Through ROS Generation and Caspase-3 Activation in Cervical Cancer Cells
- in-vitro, Cerv, HeLa - in-vitro, Nor, HaCaT
DNAdam↑, Apoptosis↑, ChemoSen↑, ROS↑, mt-ROS↑, Casp↑, Casp3↑, selectivity↑, TumCP↓, tumCV↓, eff↓,
6445- SAO,    Antineoplastic Effects of α-Santalol on Estrogen Receptor-Positive and Estrogen Receptor-Negative Breast Cancer Cells through Cell Cycle Arrest at G2/M Phase and Induction of Apoptosis
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10 - in-vitro, BC, MCF-10AT
tumCV↓, TumCP↓, selectivity↑, TumCCA↑, DNAdam↑, Casp↑, cl‑PARP↑, Casp3↑, Casp6↑, Casp7↑,
1733- SFN,    Sonic Hedgehog Signaling Inhibition Provides Opportunities for Targeted Therapy by Sulforaphane in Regulating Pancreatic Cancer Stem Cell Self-Renewal
- in-vitro, PC, PanCSC - in-vitro, Nor, HPNE - in-vitro, Nor, HNPSC
CSCs↓, Shh↓, Gli↓, Nanog↓, OCT4↓, PDGFRA↓, cycD1/CCND1↑, Apoptosis↑, Casp↑, Smo↓, Gli1↓, GLI2↓, Bcl-2↓, Casp3↑, Casp7↑,
2227- SK,    Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species
- in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, GES-1
selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,
2010- SK,    Shikonin inhibits gefitinib-resistant non-small cell lung cancer by inhibiting TrxR and activating the EGFR proteasomal degradation pathway
- in-vitro, Lung, H1975 - in-vitro, Lung, H1650 - in-vitro, Nor, CCD19
EGFR↓, selectivity↑, Casp↑, PARP↑, Apoptosis↑, ROS↑, eff↓, selectivity↑,
3142- VitC,    Vitamin C promotes apoptosis in breast cancer cells by increasing TRAIL expression
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, MCF12A
TET2↑, Apoptosis↑, TRAIL↑, BAX↑, Casp↑, Cyt‑c↑, HK2↓, PDK1 / PDPK1↓, BNIP3↓,

Showing Research Papers: 1 to 17 of 17

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH↓, 1,   GSH/GSSG↓, 1,   lipid-P↑, 1,   NADH↓, 1,   ROS↑, 10,   i-ROS?, 1,   mt-ROS↑, 2,   TrxR1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   MMP?, 1,   MMP↓, 4,   MPT↑, 1,   mtDam↑, 2,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

HK2↓, 1,   LDH↑, 1,   PDK1 / PDPK1↓, 2,   SIRT1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 4,   Apoptosis↑, 12,   BAD↑, 1,   BAX↑, 2,   Bax:Bcl2↑, 2,   Bcl-2↓, 4,   Bcl-xL↓, 2,   Casp↑, 17,   Casp3↑, 5,   cl‑Casp3↑, 2,   Casp6↑, 1,   Casp7↑, 2,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 1,   cl‑Casp9↑, 2,   Cyt‑c↑, 4,   DR5↑, 1,   Endon↑, 1,   JNK↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 1,   Mcl-1↓, 1,   p38↑, 1,   survivin↓, 1,   TRAIL↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,   tumCV↓, 5,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   IRE1↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

BNIP3↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 4,   DNArepair↓, 1,   P53↑, 2,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↑, 1,   P21↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   Diff↓, 1,   Gli↓, 1,   Gli1↓, 1,   HDAC↓, 1,   mTOR⇅, 1,   Nanog↓, 1,   OCT4↓, 1,   PDGFRA↓, 1,   PI3K↓, 2,   PTEN↑, 1,   Shh↓, 1,   Smo↓, 1,   STAT↓, 1,   STAT3↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 3,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   GLI2↓, 1,   Ki-67↓, 1,   TRIB3↑, 1,   TSC1↑, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 7,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

EGFR↓, 1,   Hif1a↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 3,   Dose↝, 1,   Dose∅, 1,   eff↓, 6,   eff↑, 5,   selectivity↑, 13,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 1,   Ki-67↓, 1,   LDH↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   Obesity↓, 1,   toxicity↓, 2,   TumVol↓, 1,   TumW↓, 2,   Weight↑, 1,   Weight∅, 1,  
Total Targets: 120

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,   ROS∅, 1,  

Cell Death(tgid=5) ⓘ

TRPV1↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   BioAv↝, 1,   BioEnh↑, 1,   Half-Life↓, 1,   Half-Life∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   neuroP↑, 1,   toxicity↓, 2,  
Total Targets: 19

Scientific Paper Hit Count for: Casp, caspase
2 chaetocin
2 Shikonin
1 Alpha-Lipoic-Acid
1 Capsaicin
1 Carvacrol
1 D-limonene
1 Docetaxel
1 Ellagic acid
1 Emodin
1 HydroxyTyrosol
1 iodine
1 Phenylbutyrate
1 Phenethyl isothiocyanate
1 Cisplatin
1 α-Santalol/Sandalwood oil
1 Sulforaphane (mainly Broccoli)
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:443  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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