Casp9 Cancer Research Results

Casp9, Caspase-9: Click to Expand ⟱

Source:

Type:

Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

359-

AgNPs,

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

in-vitro,

Lung,

A549

 9.87ug/ml

in-vitro,

Nor,

HEK293

111.3ug/ml

normal cells

Casp3↑, Casp9↑, P53↑, ROS↑, MMP2↓, MMP9↓, TumCCA↑, *toxicity↓, TumCMig↓, TumCI↓,

1078-

And,

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

in-vitro,

BC,

MDA-MB-231

5, 10, 25 and 50 μM

20uM

in-vitro,

Nor,

HUVECs

50uM

in-vivo,

BC,

MCF-7

35uM

xenografts nude mice

in-vitro,

BC,

T47D

32uM

in-vitro,

BC,

BT549

23uM

in-vitro,

BC,

MDA-MB-361

31uM

TumCP↓, COX2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

in-vitro,

PC,

AsPC-1

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

in-vivo,

NA,

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

5365-

AV,

Aloe Vera Polysaccharides as Therapeutic Agents: Benefits Versus Side Effects in Biomedical Applications

Review,

Nor,

Review,

IBD,

Review,

Diabetic,

*Wound Healing↑, *Imm↑, *antiOx↑, *AntiDiabetic↑, *AntiCan↑, *Inflam↓, *NF-kB↓, *COX2↓, *5LO↓, *IL1β↓, *IL6↓, *TNF-α↓, *IL10↑, *other↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *DNAdam↓, *GutMicro↑, *ZO-1↑, AntiTum↑, Casp3↑, Casp9↑, angioG↓, MMPs↓, VEGF↓, NK cell↑,

1533-

Ba,

Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation

in-vitro,

BrCC,

MCF-7

85μM for 24 h

in-vitro,

Nor,

MCF10

557uM

tumCV↓, i-ROS↑, MMP↓, Bcl-2↓, BAX↑, Cyt‑c↑, Casp9↑, Casp3↑, eff↓, selectivity↑, *toxicity∅, Apoptosis↑, Fenton↑,

2474-

Ba,

Anticancer properties of baicalein: a review

Review,

Var,

in-vitro,

Nor,

BV2

ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,

2686-

BBR,

Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs

Review,

Nor,

Inflam↓, IL6↓, MCP1↓, COX2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,

2024-

Bos,

Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro

in-vitro,

BC,

MCF-7

 101.1

in-vitro,

Nor,

MCF10

275.2

MMP↓, Cyt‑c↑, ROS↑, Casp8↑, Casp9↑, AntiTum↑, selectivity↑, TumCCA↑,

2014-

CAP,

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

in-vitro,

PC,

Bxpc-3

150uM

in-vitro,

Nor,

HPDE-6

150uM

normal pancreatic epithelial cells were resistant to the effects of capsaicin.

in-vivo,

PC,

AsPC-1

mice orally fed with 2.5 mg/kg capsaicin

mice, 2.5 mg/kg capsaicin was given to mice by oral gavage, which is 0.202 mg/kg when converted to human equivalent dose (HED) and equates to 13.2 mg dose of capsaicin for a 60 kg person

ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,

5880-

CAR,

In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis

vitro+vivo,

Lung,

A549

nude mice, present study commenced to formulate CANE by an energy intensive ultrasonication method.

in-vitro,

Nor,

BEAS-2B

in-vitro,

Lung,

PC9

Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,

1585-

Citrate,

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

in-vitro,

Ovarian,

SKOV3

15.93 mM

in-vitro,

Ovarian,

A2780S

16.8 mM

in-vitro,

Nor,

HEK293

Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,

1332-

EMD,

Induction of Apoptosis in HepaRG Cell Line by Aloe-Emodin through Generation of Reactive Oxygen Species and the Mitochondrial Pathway

in-vivo,

Nor,

HepaRG

rata

*tumCV↓, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↑, *Bax:Bcl2↑, *Casp3↑, *Casp8↑, *Casp9↑, *cl‑PARP↑, *TumCCA↑, *P21↑, *cycE/CCNE↑, *cycA1/CCNA1↓, *CDK2↓,

1318-

EMD,

Aloe-emodin Induces Apoptosis in Human Liver HL-7702 Cells through Fas Death Pathway and the Mitochondrial Pathway by Generating Reactive Oxygen Species

in-vitro,

Nor,

HL7702

*TumCCA↑, *ROS↑, *MMP↓, *Fas↑, *P53↑, *P21↓, *Bax:Bcl2↑, *cl‑Casp3↑, *cl‑Casp8↑, *cl‑Casp9↑, *cl‑PARP↑,

2841-

FIS,

Fisetin, an Anti-Inflammatory Agent, Overcomes Radioresistance by Activating the PERK-ATF4-CHOP Axis in Liver Cancer

in-vitro,

Nor,

RAW264.7

LPS-induced Raw264.7 cells

in-vitro,

Liver,

HepG2

10, 25, 100, and 200 μM, 24 h

in-vitro,

Liver,

Hep3B

in-vitro,

Liver,

HUH7

*Inflam↓, *TNF-α↓, *IL1β↓, *IL6↓, Apoptosis↓, ER Stress↑, Ca+2↑, PERK↑, ATF4↑, CHOP↑, GRP78/BiP↑, tumCV↓, LDH↑, Casp3↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, p‑eIF2α↑, RadioS↑,

823-

GAR,

Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

in-vitro,

CRC,

HCT116

Casp3↑, Casp9↑, Casp8↑, DR5↑, survivin↓, Bcl-2↓, XIAP↓, cFLIP↓, BAX↑, Cyt‑c↑, ROS↑, GSH↓, *eff↓,

841-

Gra,

The Chemopotential Effect of Annona muricata Leaves against Azoxymethane-Induced Colonic Aberrant Crypt Foci in Rats and the Apoptotic Effect of Acetogenin Annomuricin E in HT-29 Cells: A Bioassay-Guided Approach

in-vitro,

CRC,

HT-29

1.62ug/ml@48hr

in-vitro,

Nor,

CCD841

32.51μg/ml@48 h

normal human colon cells

PCNA↓, Bcl-2↓, BAX↑, *MDA↓, lipid-P↓, TumCG↓, MMP↓, Cyt‑c↑, Casp3↑, Casp7↑, Casp9↑, *ROS↓, LDH↓, *toxicity↓, selectivity↑,

851-

Gra,

Antiproliferation Activity and Apoptotic Mechanism of Soursop (Annona muricata L.) Leaves Extract and Fractions on MCF7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

f 5.3, 2.86, 3.08, and 48.31 µg/mL

ethanol extract, ethyl acetate, n-hexane, and water fractions of A. muricata leaves

in-vitro,

Nor,

CV1

Bcl-2↓, Casp9↑, Casp3↑, other↑, *toxicity↓,

849-

Gra,

Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis

in-vitro,

Pca,

PC3

 48.17μg/ml

in-vitro,

Nor,

PNT1A

7.8x higher

normal health cells

in-vitro,

NA,

HeLa

Casp9↑, CXCL1↓, *toxicity↓,

2915-

LT,

Luteolin promotes apoptotic cell death via upregulation of Nrf2 expression by DNA demethylase and the interaction of Nrf2 with p53 in human colon cancer cells

in-vitro,

Colon,

HT29

30 μM

in-vitro,

CRC,

SNU-407

30 μM

in-vitro,

Nor,

FHC

65 μM

DNMTs↓, TET1↑, NRF2↑, HDAC↓, tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, ROS↓, GSS↑, Catalase↑, HO-1↑, DNMT1↓, DNMT3A↓, TET1↑, TET3↑, TET2↓, P53↑, P21↑,

2006-

PLB,

Plumbagin induces apoptosis in human osteosarcoma through ROS generation, endoplasmic reticulum stress and mitochondrial apoptosis pathway

in-vitro,

OS,

MG63

in-vitro,

Nor,

hFOB1.19

tumCV↓, selectivity↑, mtDam↑, Ca+2↓, ER Stress↑, ROS↑, Casp3↑, Casp9↑, Apoptosis↑, eff↓,

3353-

QC,

Quercetin triggers cell apoptosis-associated ROS-mediated cell death and induces S and G2/M-phase cell cycle arrest in KON oral cancer cells

in-vitro,

Oral,

KON

 0, 1.5625, 3.125, 6.25, 12.5, 25, 50, 100, and 400 µg/mL

50ug/L @ 72h

in-vitro,

Nor,

MRC-5

tumCV↓, selectivity↑, TumCCA↑, TumCMig↓, TumCI↓, Apoptosis↑, TumMeta↓, Bcl-2↓, BAX↑, TIMP1↑, MMP2↓, MMP9↓, *Inflam↓, *neuroP↑, *cardioP↑, p38↓, MAPK↓, Twist↓, P21↓, cycD1/CCND1↓, Casp3↑, Casp9↑, p‑Akt↓, p‑ERK↓, CD44↓, CD24↓, ChemoSen↑, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑, Hif1a↓, VEGF↓,

3325-

SIL,

Modulatory effect of silymarin on pulmonary vascular dysfunction through HIF-1α-iNOS following rat lung ischemia-reperfusion injury

in-vivo,

Nor,

Rats

*Inflam↓, *ROS↓, *Casp3↑, *Casp9↑, *Hif1a↓, *iNOS↓, *SOD↑, *MDA↓,

2007-

SK,

Shikonin Directly Targets Mitochondria and Causes Mitochondrial Dysfunction in Cancer Cells

in-vitro,

lymphoma,

U937

<10uM

in-vitro,

BC,

MCF-7

in-vitro,

BC,

SkBr3

in-vitro,

CRC,

HCT116

in-vitro,

OS,

U2OS

NA,

Nor,

RPE-1

RPE-1-GFP-EB3 cells were treated with 25 μM shikonin

tumCV↓, selectivity↑, Dose↝, other↑, MMP↓, ROS↑, DNAdam↑, Ca+2↑, Casp9↑, Cyt‑c↑, *toxicity↓,

2110-

TQ,

Nigella sativa seed oil suppresses cell proliferation and induces ROS dependent mitochondrial apoptosis through p53 pathway in hepatocellular carcinoma cells

in-vitro,

HCC,

HepG2

50–250 μg/ml) of NSO

44.6 μg/ml

in-vitro,

BC,

MCF-7

46.2 μg/ml

in-vitro,

Lung,

A549

245 μg/ml

in-vitro,

Nor,

HEK293

1136 μg/ml

indicates selectivity

P53↑, lipid-P↑, GSH↓, ROS↑, MMP↓, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, tumCV↓, selectivity↑,

Showing Research Papers: 1 to 24 of 24

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:

Functional Outcomes ⓘ

AntiTum↑, 3, TumW↓, 2, Weight↑, 1,
Total Targets: 189

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 1, Catalase↑, 1, GPx↑, 1, lipid-P↓, 1, MDA↓, 2, ROS↓, 4, ROS↑, 2, ROS∅, 1, SOD↑, 2,

Mitochondria & Bioenergetics ⓘ

MMP↓, 2,

Cell Death ⓘ

Akt↓, 1, Bax:Bcl2↑, 2, Casp3↑, 2, cl‑Casp3↑, 1, Casp8↑, 1, cl‑Casp8↑, 1, Casp9↑, 2, cl‑Casp9↑, 1, Fas↑, 2, iNOS↓, 2,

Transcription & Epigenetics ⓘ

other↓, 1, tumCV↓, 1,

DNA Damage & Repair ⓘ

DNAdam↓, 1, P53↑, 2, cl‑PARP↑, 2,

Cell Cycle & Senescence ⓘ

CDK2↓, 1, cycA1/CCNA1↓, 1, cycE/CCNE↑, 1, P21↓, 1, P21↑, 2, TumCCA↑, 2,

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,

Migration ⓘ

5LO↓, 1, ZO-1↑, 1,

Angiogenesis & Vasculature ⓘ

angioG↓, 1, Hif1a↓, 2, VEGF↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 2, IL10↑, 1, IL1β↓, 2, IL6↓, 2, Imm↑, 1, Inflam↓, 4, NF-kB↓, 1, TNF-α↓, 2,

Drug Metabolism & Resistance ⓘ

eff↓, 1,

Clinical Biomarkers ⓘ

GutMicro↑, 1, IL6↓, 2,

Functional Outcomes ⓘ

AntiCan↑, 1, AntiDiabetic↑, 1, cardioP↑, 1, neuroP↑, 1, toxicity↓, 6, toxicity∅, 2, Wound Healing↑, 1,
Total Targets: 55

Scientific Paper Hit Count for: Casp9, Caspase-9

3 Graviola
2 Baicalein
2 Emodin
1 Silver-NanoParticles
1 Andrographis
1 Apigenin (mainly Parsley)
1 Metformin
1 Aloe anthraquinones
1 Berberine
1 Boswellia (frankincense)
1 Capsaicin
1 Carvacrol
1 Citric Acid
1 Fisetin
1 Garcinol
1 Luteolin
1 Plumbagin
1 Quercetin
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Thymoquinone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:45  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

Casp9 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Immune & Inflammatory Signaling ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

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