AMPKα Cancer Research Results

AMPKα, AMP-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK is a heterotrimeric protein complex consisting of three subunits: AMPKα, AMPKβ, and AMPKγ. AMPKα is expressed in two isoforms, AMPKα1 and AMPKα2, and these isoforms are encoded by the genes PRKAA1 and PRKAA2, respectively.
In many cancers, AMPKα acts as a tumor suppressor, and its downregulation is often associated with worse clinical outcomes.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5784- EGCG,    Dietary Epicatechin Promotes Survival of Obese Diabetic Mice and Drosophila melanogaster
- in-vivo, Nor, NA
*OS↑, *Inflam↓, *LDL↓, *AntiAge↑, *GSH↑, *SOD↑, *AMPKα↑, *Weight∅,
2135- TQ,    Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets
- in-vitro, Nor, HaCaT
*HO-1↑, *NRF2↑, *e-ERK↑, *e-Akt↑, *AMPKα↑, *ROS⇅, *eff↓, *tumCV∅,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS⇅, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 1,  

Cell Death ⓘ

e-Akt↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 2,  

Transcription & Epigenetics ⓘ

tumCV∅, 1,  

Proliferation, Differentiation & Cell State ⓘ

e-ERK↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   OS↑, 1,   Weight∅, 1,  
Total Targets: 15

Scientific Paper Hit Count for: AMPKα, AMP-activated protein kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:475  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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