TAC Cancer Research Results

TAC, total antioxidant capacity: Click to Expand ⟱
Source:
Type:
Total antioxidant capacity (TAC) refers to the ability of a biological sample (such as blood, tissues, or food) to counteract oxidative stress by neutralizing free radicals and reactive oxygen species (ROS).

May have reduced levels in cancers.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
2317- Api,    Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1α mediated oxidative stress
- in-vivo, Nor, NA
*hepatoP↑, *PKM2↓, *Hif1a↓, *MDA↓, *Catalase↓, *GSH↑, *SOD↑, *GPx↑, *TAC↑, *α-SMA↓, *Vim↓, *ROS↓,
5755- CA,    Caffeic Acid as a Promising Natural Feed Additive: Advancing Sustainable Aquaculture
- Review, Nor, NA
*Imm↑, *Inflam↓, *Bacteria↓, *eff↑, *ROS↓, *MDA↓, *Catalase↑, *GSH↑, *TAC↑, *NF-kB↓, *NLRP3↓, *eff↑, *AST↓, *ALAT↓, *SOD↑, *GSTA1↑,
5873- CA,    Carnosic acid serves as a dual Nrf2 activator and PTEN/AKT suppressor to inhibit traumatic heterotopic ossification
- vitro+vivo, Nor, NA
*NRF2↑, *NOX↓, *TAC↑, *ROS↓, *NQO1↑, *p‑PTEN↑, RUNX2↓, SOX9↓,
3528- Lyco,    The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene
- Review, Nor, NA - Review, AD, NA - Review, Park, NA
*antiOx↑, *ROS↓, *BioAv↝, *Half-Life↑, *BioAv↓, *BioAv↑, *cardioP↑, *neuroP↑, *H2O2↓, *VitC↑, *VitE↑, *GPx↑, *GSH↑, *MPO↓, *GSTs↓, *SOD↑, *NF-kB↓, *IL1β↓, *IL6↓, *IL10↑, *MAPK↓, *Akt↓, *COX2↓, *TNF-α↓, *TGF-β1↑, *NO↓, *GSR↑, *NRF2↑, *HO-1↑, *TAC↑, *Inflam↓, *BBB↑, *neuroP↑, *memory↑,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
3014- RosA,    Rosmarinic Acid Supplementation Acts as an Effective Antioxidant for Restoring the Antioxidation/Oxidation Balance in Wistar Rats with Cadmium-Induced Toxicity
- in-vivo, Nor, NA
*antiOx↑, *Thiols↑, *GSH↑, *TAC↑, *SOD↑, *GPx↑, *Catalase↑, *ALP↓, *ALAT↓, *AST↓, *creat↓, *BUN↓, *H2O2↓, *MDA↓, *ROS↓, cardioP↑, hepatoP↑, neuroP↑,
4601- SeNPs,  AgNPs,    Antioxidant and hepatoprotective role of selenium against silver nanoparticles
- in-vivo, Nor, NA
*TAC↑, *CRP↓, *AST↓, *ALAT↓, *toxicity↓, *GSH↑, *SOD↑, *Catalase↑, *hepatoP↑,
3329- SIL,    Silymarin regulates the HIF-1 and iNOS expression in the brain and Gills of the hypoxic-reoxygenated rainbow trout (Oncorhynchus mykis)
- in-vivo, Nor, NA
*NO↓, *MDA↓, *TAC↑, *Hif1a↓, *iNOS↓,
2220- SK,    Shikonin Alleviates Gentamicin-Induced Renal Injury in Rats by Targeting Renal Endocytosis, SIRT1/Nrf2/HO-1, TLR-4/NF-κB/MAPK, and PI3K/Akt Cascades
- in-vivo, Nor, NA
*RenoP↑, *ROS↓, *SIRT1↓, *NRF2↑, *HO-1↑, *GSH↑, *TAC↑, *SOD↑, *MDA↓, *NO↓, *iNOS↓, *NHE3↑, *PI3K↑,
5338- TFdiG,    Isolation and antioxidant characterization of theaflavin for neuroprotective effect in mice model
- in-vivo, Nor, NA
*antiOx↑, *TOS↑, *TAC↑, *neuroP↑,
3398- TQ,  5-FU,    Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo
- in-vivo, Nor, NA
*RenoP↑, *TAC↑, *ROS↓, *lipid-P↓, *p38↓, *MAPK↓, *NF-kB↓, *NRF2↑, *HO-1↑, *MDA↓, *GPx↑, *GSR↑, *Catalase↑, *BUN↓, *LDH↓, *IL1β↓,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Kinase & Signal Transduction ⓘ

SOX9↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

RUNX2↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   Risk↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↓, 1,   Catalase↑, 4,   GPx↑, 4,   GSH↑, 6,   GSR↑, 2,   GSTA1↑, 1,   GSTs↓, 1,   H2O2↓, 2,   HO-1↑, 3,   lipid-P↓, 1,   MDA↓, 6,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 5,   ROS↓, 8,   SOD↑, 6,   SOD2↑, 1,   TAC↑, 11,   Thiols↑, 1,   TOS↑, 1,   TrxR1↑, 1,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 4,   AMPK↑, 1,   BUN↓, 2,   CRM↑, 1,   LDH↓, 1,   LDL↓, 1,   PKM2↓, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 1,   iNOS↓, 2,   MAPK↓, 2,   p38↓, 1,  

Protein Folding & ER Stress ⓘ

NQO2↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↑, 1,   p‑PTEN↑, 1,  

Migration ⓘ

TGF-β1↑, 1,   Vim↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 2,   NO↓, 3,  

Barriers & Transport ⓘ

BBB↑, 1,   NHE3↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CRP↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 3,   NF-kB↓, 3,   TNF-α↓, 1,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   eff↑, 2,   Half-Life↑, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 4,   ALP↓, 1,   AST↓, 3,   creat↓, 1,   CRP↓, 1,   IL6↓, 1,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   hepatoP↑, 2,   memory↑, 1,   neuroP↑, 3,   RenoP↑, 2,   Strength↑, 1,   toxicity↓, 1,   toxicity⇅, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 80

Scientific Paper Hit Count for: TAC, total antioxidant capacity
1 Apigenin (mainly Parsley)
1 Caffeic acid
1 Carnosic acid
1 Lycopene
1 Metformin
1 Rosmarinic acid
1 Selenium NanoParticles
1 Silver-NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Aflavin-3,3′-digallate
1 Thymoquinone
1 5-fluorouracil
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:626  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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