AMPK Cancer Research Results

AMPK, adenosine monophosphate-activated protein kinase: Click to Expand ⟱
Source:
Type:
AMPK: guardian of metabolism and mitochondrial homeostasis; Upon changes in the ATP-to-AMP ratio, AMPK is activated. (AMPK) is a key metabolic sensor that is pivotal for the maintenance of cellular energy homeostasis. It is well documented that AMPK possesses a suppressor role in the context of tumor development and progression by modulating the inflammatory and metabolic pathways.

-Activating AMPK can inhibit anabolic processes and the PI3K/Akt/mTOR pathway reducing glycolysis shifting toward Oxidative Phosphorlylation.


AMPK activators:
-metformin or AICAR
-Resveratrol: activate AMPK indirectly
-Berberine
-Quercetin: may stimulate AMPK
-EGCG: thought to activate AMPK
-Curcumin: may activate AMPK

-Ginsenosides: Some ginsenosides have been associated with AMPK activation -Beta-Lapachone: A natural naphthoquinone compound found in the bark of Tabebuia avellanedae (also known as lapacho or taheebo). It has been observed to activate AMPK in certain models.
-Alpha-Lipoic Acid (ALA): associated with AMPK activation
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
2318- Api,    Apigenin as a multifaceted antifibrotic agent: Therapeutic potential across organ systems
- Review, Nor, NA
*ROS↓, *PKM2↓, *Hif1a↓, *TGF-β↓, *AMPK↑, *Inflam↓, *PI3K↓, *Akt↑, *NRF2↑, *NF-kB↓,
2696- BBR,    Berberine regulates proliferation, collagen synthesis and cytokine secretion of cardiac fibroblasts via AMPK-mTOR-p70S6K signaling pathway
- in-vivo, Nor, NA
*α-SMA↓, *TGF-β1↓, *IL10↑, *p‑AMPK↑, *p‑mTOR↓, *P70S6K↓, *cardioP↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
6510- BCP,  CBD,    Cannabidiol and Beta-Caryophyllene Combination Attenuates Diabetic Neuropathy by Inhibiting NLRP3 Inflammasome/NFκB through the AMPK/sirT3/Nrf2 Axis
- in-vivo, Nor, NA
*MMP↓, *ROS↑, *BloodF↑, *Pain↓, *antiOx↑, *Inflam↓, *AMPK↑, *SIRT3↑, *NRF2↑, *PINK1↑, *PARK2↑, *LC3B↑, *Beclin-1/ATG6↑, *TFAM↑, *NLRP3↓, *NF-kB↓, *COX2/PTGS2↓, *p62↓, *NP/CIPN↓,
5509- bemA,    Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis
- Review, Nor, NA
LDL↓, AMPK↑, ACLY↓,
2739- BetA,    Glycolytic Switch in Response to Betulinic Acid in Non-Cancer Cells
- in-vitro, Nor, HUVECs - in-vitro, Nor, MEF
*Glycolysis↑, *GlucoseCon↑, *Apoptosis↓, *UCP1↓, *AMPK↑, GLUT1↑, mt-ROS↑,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5834- CAP,    Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
- Study, Nor, NA
*AntiCan↑, *Inflam↓, *antiOx↑, *TRPV1↑, *AMPK↑, *SIRT1↑, *NADPH↓, *ROS↓, *MAPK↓, *eNOS↑, *Wnt/(β-catenin)↓, RenoP↑,
2348- CAP,    Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
- Analysis, Nor, NA
Warburg↓, *PKM2↓, *COX2/PTGS2↓, *Inflam↓, *Sepsis↓, *AMPK↑, *PKA↑, *mitResp↑, *FAO↑, *FASN↓, *PGM1?, *ATP↑, *ROS↓,
6622- Cic,    Chicoric Acid Is an Antioxidant Molecule That Stimulates AMP Kinase Pathway in L6 Myotubes and Extends Lifespan in Caenorhabditis elegans
- in-vivo, Nor, NA
*ROS↓, *AMPK↑, *GPx↑, *SOD↑, *SOD2↑, *PGC-1α↑, *Akt↓, *mTOR↓, *Insulin↓, *antiOx↑, *AntiAge↑,
5792- CRMs,  HCA,  CUR,  EGCG,  GAR  Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers
- Review, Nor, NA
*CRM↓, *Dose?, *AntiAge↑, *Acetyl-CoA↓, *SIRT1↑, *AMPK↑, *mTORC1↓, *AntiAge↑, chemoP↑,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
951- DHA,    Docosahexaenoic Acid Attenuates Breast Cancer Cell Metabolism and the Warburg Phenotype by Targeting Bioenergetic Function
- in-vitro, BC, BT474 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
Hif1a↓, GLUT1↓, LDH↓, GlucoseCon↓, lactateProd↓, ATP↓, p‑AMPK↑, ECAR↓, OCR↓, *toxicity↓,
5068- dietSTF,    mTOR-autophagy axis regulation by intermittent fasting promotes skeletal muscle growth and differentiation
- in-vivo, Nor, NA
*glucose↓, ROS↑, LC3B↑, p62↓, p‑mTOR↓, p‑AMPK↑,
6327- DRE,    Effect of Methanolic Extract of Dandelion Roots on Cancer Cell Lines and AMP-Activated Protein Kinase Pathway
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF7 - in-vitro, CRC, HCT116 - in-vitro, Nor, Hs27
TumCG↓, selectivity↑, p‑AMPK↑,
3214- EGCG,    EGCG-induced selective death of cancer cells through autophagy-dependent regulation of the p62-mediated antioxidant survival pathway
- in-vitro, Nor, MRC-5 - in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293 - in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
mTOR↓, AMPK↑, selectivity↑, ROS↑, selectivity↑, HO-1↓, *NRF2↑, NRF2↓, *HO-1↑,
6825- EMD,    Advances in the pharmacological effects and molecular mechanisms of emodin in the treatment of metabolic diseases
- Review, Nor, NA
*Inflam↓, *AntiTum↑, *Bacteria↓, *Imm↑, *glucose↓, *RenoP↑, *TLR4↓, *MyD88↓, *NLRP3↓, *NF-kB↓, *PI3K↓, *mTOR↓, *GSK‐3β↓, *Hif1a↓, *VEGF↓, *GutMicro↑, *Obesity↓, *AntiDiabetic↑, *AMPK↑, *PPARγ↑, *PPARγ↓, *toxicity↝, *hepatoP↑, *AST↓, *ALAT↓,
6836- EMD,    Emodin and the Anthraquinone Scaffold: Therapeutic Promise and Strategies to Overcome Translational Barriers
- Review, Nor, NA
*antiOx↑, *neuroP↑, *Inflam↓, *hepatoP↑, AntiTum↑, *Bacteria↓, *diuretic↑, *AntiDiabetic↑, *BioAv↝, *NF-kB↓, *AMPK↑, *JAK↓, *STAT3↓, *ROS↓, *lipid-P↓, ROS↑, TumCCA↑, CycB/CCNB1↓, BAX↑, Bcl-2↓, MOMP↑, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, Apoptosis↑, P53↑,
6897- FIS,    Fisetin: A Dietary Antioxidant for Health Promotion
- Review, Nor, NA
*chemoPv↑, *neuroP↑, *antiOx↑, *GSH↑, *HO-1↑, *NRF2↑, angioG↓, TumCG↓, uPA↓, MMP1↓, tumCV↓, PTEN↑, PI3K↓, p‑Akt↓, AMPK↑, mTOR↓, EGFR↓, NF-kB↓, COX2/PTGS2↓, PGE2↓, Wnt↓, β-catenin/ZEB1↓, TCF↓, cycD1/CCND1↓, MMP7↓, RadioS↑, PSA↓, Securin↓, TumCCA↑, XIAP↓, *ERK↑, *p‑CREB↑, *memory↑, *GSH↑, *Inflam↓, *5LO↓,
2860- FIS,    Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3 - in-vitro, Nor, hTERT-HPNE - in-vivo, NA, NA
AMPK↑, mTOR↑, UPR↑, ER Stress↑, selectivity↑, TumCP↓, PERK↑, ATF4↑, ATF6↑,
1186- GAs,    Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis
- in-vitro, PC, NA - in-vitro, Nor, HUVECs - in-vivo, PC, NA
tumCV↓, *toxicity∅, TumCMig↓, TumCI↓, Apoptosis↑, AMPK↑, lipoGen↓, ACC↓, FASN↓,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
7800- ISQ,    Isoquercitrin Attenuates Oxidative Liver Damage Through AMPK-YAP Signaling: An Integrative In Silico, In Vitro, and In Vivo Study
- vitro+vivo, Nor, HepG2
*antiOx↑, *Inflam↓, *AntiCan↑, *ROS↓, *MMP↑, *STK11/LKB1↑, *AMPK↑, *p‑AMPK↑, *ACC↑, *ALAT↓, *AST↓, *hepatoP↑,
7982- itraC,    Simultaneous Targeting of NPC1 and VDAC1 by Itraconazole Leads to Synergistic Inhibition of mTOR Signaling and Angiogenesis
- in-vitro, Nor, HUVECs - in-vitro, Lung, A549 - in-vitro, Cerv, HeLa - in-vitro, Nor, HEK293
angioG↓, mTOR↓, NPC1L1↓, AMPK↑, VDAC1↓,
7983- itraC,    Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells
- in-vitro, Nor, HUVECs
angioG↓, VDAC1↓, mt-ATP↓, AMPK↑, mTOR↓, TumCP↓,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
8155- lamb,    Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK)
- vitro+vivo, Nor, 3T3
*p‑AMPK↑, *PPARγ↓, *CEBPA↓, *adiP↓, *Fas↓, *SREBP1/SREBF1↓, *HMGCR↓, *lipidLev↓, *TG/TAG↓, *Weight↓, *LDL↓, *Obesity↓,
8229- LCA,    Licochalcone A: a review of its pharmacology activities and molecular mechanisms
- Review, Nor, NA
*Inflam↓, *NO↓, *NF-kB↓, *TAC↑, Apoptosis?, TumCCA↑, TumCI↓, TumMeta↓, TumCP↓, MAPK↓, Akt↓, IL6↓, IL8↓, VEGFR2/KDR/Flk1↓, LC3II↑, PI3K↓, mTOR↓, mtDam↑, MMP↓, *NRF2↑, *PGE2↓, *Obesity↓, *SIRT1↑, *AMPK↑, *AntiFungal↑, *AntiP↑, *BMD↑, *GastroP↑,
2921- LT,    Luteolin as a potential hepatoprotective drug: Molecular mechanisms and treatment strategies
- Review, Nor, NA
*hepatoP↑, *AMPK↑, *SIRT1↑, *ROS↓, STAT3↓, TNF-α↓, NF-kB↓, *IL2↓, *IFN-γ↓, *GSH↑, *SREBP1/SREBF1↓, *ZO-1↑, *TLR4↓, BAX↑, Bcl-2↓, XIAP↓, Fas↑, Casp8↑, Beclin-1/ATG6↑, *TXNIP↓, *Casp1↓, *IL1β↓, *IL18↓, *NLRP3↓, *MDA↓, *SOD↑, *NRF2↑, *ER Stress↓, *ALAT↓, *AST↓, *iNOS↓, *IL6↓, *HO-1↑, *NQO1↑, *PPARα↑, *ATF4↓, *CHOP/DDIT3↓, *Inflam↓, *antiOx↑, *GutMicro↑,
3265- Lyco,    Lycopene inhibits pyroptosis of endothelial progenitor cells induced by ox-LDL through the AMPK/mTOR/NLRP3 pathway
- in-vitro, Nor, NA
*AMPK↑, *mTOR↓, *NLRP3↓, *Pyro↓,
6537- MeSal,    The ancient drug salicylate directly activates AMP-activated protein kinase
- Review, Nor, NA
*BioAv↝, *AMPK↑, *Half-Life↝,
5785- MET,    Metformin improves healthspan and lifespan in mice
- in-vivo, Nor, NA
*AntiDiabetic↑, *AntiAge↑, *toxicity⇅, *CRM↑, *Strength↑, *LDL↓, *AMPK↑, *TAC↑, *ROS↓, *Inflam↓, Risk↓, *cardioP↑, *ALAT↓, *NRF2↑, *SOD2↑, *TrxR1↑, *NQO1↑, *NQO2↑,
2492- MET,    The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective
- Review, Nor, NA
*glucose↓, *glucoNG↓, *AMPK↑,
3499- MFrot,  MF,    Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans
- in-vitro, Nor, HUVECs
*AntiAge↑, *AMPK↑, *mPGES-1↓, *Ca+2↑, *ER Stress↑, *OS↑, *ROS↓,
5781- RES,    Resveratrol improves health and survival of mice on a high-calorie diet
- in-vivo, Nor, NA
*AntiAge↑, *IGF-1↓, *AMPK↑, *CRM↑, *PGC-1α↑, *mtDam↓, *motorD↑, *hepatoP↑, *Dose↝,
5788- RES,    Calorie restriction-like effects of 30 days of Resveratrol (resVida™) supplementation on energy metabolism and metabolic profile in obese humans
- Trial, Nor, NA
*AMPK↑, *SIRT1↑, *PGC-1α↑, *BP↓, *CRM↑, *Dose↝, *mtDam↓, *ALAT↓, *hepatoP↑,
3099- RES,    Resveratrol and cognitive decline: a clinician perspective
- Review, Nor, NA - NA, AD, NA
*antiOx↑, *ROS↓, *cognitive↑, *neuroP↑, *SIRT1↑, *AMPK↑, *GPx↑, *HO-1↑, *GSK‐3β↑, *COX2/PTGS2↓, *PGE2↓, *NF-kB↓, *NO↓, *Casp3↓, *MMP3↓, *MMP9↓, *MMP↑, *GSH↑, *other↑, *BioAv↑, *memory↑, *GlutMet↑, *BioAv↓, *Half-Life↓, *toxicity∅,
3056- RES,    Less is more for cancer chemoprevention: evidence of a non-linear dose response for the protective effects of resveratrol in humans and mice
- in-vivo, Nor, NA
*AMPK↑, *P21↑, *Dose↓, *chemoPv↑,
3069- RES,    Resveratrol Inhibits NLRP3 Inflammasome-Induced Pyroptosis and miR-155 Expression in Microglia Through Sirt1/AMPK Pathway
- in-vitro, Nor, N9
*antiOx↑, *Inflam↓, *ROS↓, *NF-kB↓, *AMPK↑, *SIRT1↑, *miR-155↓, *NLRP3↓,
7951- RT,  BuckWS,    The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives
- Review, Nor, NA
*Dose↝, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↓, *BioAv↝, TumCP↓, Risk↓, *radioP↑, chemoPv↑, TumCCA↑, GSK‐3β↑, Wnt↓, β-catenin/ZEB1↓, ROS↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, PARP↑, Beclin-1/ATG6↑, ATG5↑, LC3II↑, DNMT1↓, P21↑, CDK1↑, CycB/CCNB1↓, TNF-α↑, VEGF↓, IL1β↓, NF-kB↓, AP-1↓, MYCN↓, AMPK↑, MAPK↓, PI3K↓, Akt↓, cMET↓, P-gp/ABCB1↓, MRP1/ABCC1↓, ABCG2↓, MMPs↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, angioG↓, STAT3↓, *chemoP↑, *ROS↓, *MDA↓, *P53↓, *Casp3↓, *Casp9↓, *JNK↓, *TNF-α↓, *p38↓, *MAPK↓, GSH↓, ChemoSen↑, *hepatoP↑, *COX1↓, *COX2/PTGS2↓, *15-LOX/ALOX15↓, RenoP↑, *toxicity↓,
3186- SFN,    A pharmacological inhibitor of NLRP3 inflammasome prevents non-alcoholic fatty liver disease in a mouse model induced by high fat diet
- in-vivo, Nor, NA
*NLRP3↓, *ASC↓, *Casp1↓, *IL1β↓, *ALAT↓, *AST↓, *AMPK↑, *mTOR↓, *P70S6K↓,
2218- SK,    Shikonin Alleviates Endothelial Cell Injury Induced by ox-LDL via AMPK/Nrf2/HO-1 Signaling Pathway
- in-vitro, Nor, HUVECs
*Dose↝, *Apoptosis↓, *Casp3↓, *Bcl-2↑, *Inflam↓, *VCAM-1↓, *ICAM-1↓, *E-sel↓, *ROS↓, *SOD↑, *AMPK↑, *NRF2↑, *HO-1↑, *TNF-α↓, *IL1β↓, *IL6↓,
7036- TBE,  GA,    Terminalia bellirica (Gaertn.) Roxb. Extract and Gallic Acid Attenuate LPS-Induced Inflammation and Oxidative Stress via MAPK/NF-κB and Akt/AMPK/Nrf2 Pathways
- in-vitro, Nor, THP1 - in-vitro, Nor, RAW264.7
*ROS↓, *MAPK↓, *NF-kB↓, *TAC↑, *NRF2↑, *Akt↑, *AMPK↑, *Inflam↓,
4862- Uro,    Neuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease
- in-vivo, AD, NA - in-vitro, Nor, PC12
*cognitive↑, *p‑PI3K↓, *p‑Akt↓, *AMPK↑, *VDAC1↓, *neuroP↑, *PARK2↑, *PTEN↑, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p62↓, *Aβ↓, *Apoptosis↓,

Showing Research Papers: 1 to 46 of 46

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 46

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

MYCN↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GSH↓, 1,   HO-1↓, 1,   Iron↑, 2,   MDA↑, 1,   NRF2↓, 1,   PARK2↑, 1,   RNS↑, 1,   ROS↑, 8,   mt-ROS↑, 1,   VDAC1↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   NCOA4↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   mt-ATP↓, 1,   MEK↓, 1,   MMP↓, 3,   mtDam↑, 1,   OCR↓, 1,   PINK1↑, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ACLY↓, 1,   AMPK↑, 11,   p‑AMPK↑, 4,   ATG7↑, 1,   ECAR↓, 1,   FASN↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDL↓, 1,   lipoGen↓, 1,   NPC1L1↓, 1,   p‑S6K↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   Apoptosis?, 1,   Apoptosis↑, 3,   Bak↑, 1,   BAX↑, 5,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Bcl-xL↓, 1,   Casp3↑, 4,   cl‑Casp3↑, 1,   Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 1,   MAPK↓, 2,   MOMP↑, 1,   p27/CDKN1B↑, 1,   Telomerase↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   ER Stress↑, 2,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↑, 3,   p62↓, 3,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNMT1↓, 1,   P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↑, 1,   CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 1,   Securin↓, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   CD133↓, 1,   cMET↓, 1,   CSCs↓, 1,   Diff↓, 1,   EMT↓, 1,   ERK↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   mTOR↓, 6,   mTOR↑, 2,   p‑mTOR↓, 1,   p‑mTORC1↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   PI3K↓, 4,   PTEN↑, 2,   SOX2↓, 1,   STAT3↓, 3,   TCF↓, 1,   TumCG↓, 3,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   E-cadherin↑, 1,   miR-139-5p↑, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP7↓, 1,   MMP9↓, 1,   MMPs↓, 1,   N-cadherin↓, 1,   Snail↓, 1,   TumCI?, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 5,   TumCP↑, 1,   TumMeta↓, 2,   uPA↓, 2,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 4,   ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 3,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,   GLUT1↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   COX2/PTGS2↓, 3,   CXCR4↓, 1,   IL1β↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 1,   JAK2↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   PGE2↓, 3,   PSA↓, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   ChemoSen↑, 2,   Dose?, 1,   Dose↓, 1,   Dose↑, 1,   eff↓, 1,   eff↑, 3,   eff↝, 1,   MRP1/ABCC1↓, 1,   RadioS↑, 2,   selectivity↑, 5,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   IL6↓, 2,   LDH↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 2,   chemoP↑, 1,   chemoPv↑, 2,   RenoP↑, 2,   Risk↓, 2,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 175

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   AntiP↑, 1,   diuretic↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   CYP2E1↓, 1,   GCLC↑, 1,   GCLM↑, 1,   GPx↑, 2,   GSH↑, 5,   HO-1↑, 6,   Keap1↓, 1,   lipid-P↓, 1,   MDA↓, 3,   NQO1↑, 3,   NRF2↑, 11,   PARK2↑, 2,   ROS↓, 16,   ROS↑, 1,   SIRT3↑, 1,   SOD↑, 5,   SOD2↑, 2,   TAC↑, 3,   Trx1↑, 1,   TrxR1↑, 1,   VDAC1↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   Insulin↓, 1,   Insulin↑, 1,   mitResp↑, 1,   MMP↓, 1,   MMP↑, 3,   mtDam↓, 2,   PGC-1α↑, 3,   PINK1↑, 1,   UCP1↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   Acetyl-CoA↓, 1,   adiP↓, 1,   ALAT↓, 7,   AMPK↑, 29,   p‑AMPK↑, 4,   p‑CREB↑, 1,   CRM↓, 1,   CRM↑, 3,   FAO↑, 1,   FASN↓, 1,   glucoNG↓, 1,   glucose↓, 4,   GlucoseCon↑, 1,   GlutMet↑, 1,   Glycolysis↑, 1,   LDL↓, 2,   lipidLev↓, 2,   NADPH↓, 1,   PGM1?, 1,   PKM2↓, 2,   PPARα↑, 1,   PPARγ↓, 2,   PPARγ↑, 1,   SIRT1↑, 9,   SREBP1/SREBF1↓, 2,   STK11/LKB1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 3,   p‑Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↓, 3,   BAX↓, 1,   Bcl-2↑, 1,   Casp1↓, 2,   Casp3↓, 4,   Casp8↓, 1,   Casp9↓, 2,   Cyt‑c↓, 1,   Fas↓, 1,   iNOS↓, 2,   JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 3,   p38↓, 1,   Pyro↓, 1,   TRPV1↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   TFAM↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   ER Stress↑, 1,   NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   p62↓, 2,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CEBPA↓, 1,   ERK↑, 1,   p‑ERK↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   p‑GSK‐3β↑, 1,   HMGCR↓, 1,   IGF-1↓, 1,   mTOR↓, 5,   p‑mTOR↓, 1,   mTORC1↓, 1,   P70S6K↓, 2,   PI3K↓, 2,   p‑PI3K↓, 1,   p‑PI3K↑, 1,   PTEN↑, 1,   STAT3↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,   Ca+2↑, 1,   COL1↓, 1,   E-sel↓, 1,   miR-155↓, 1,   MMP3↓, 1,   MMP9↓, 1,   PKA↑, 1,   p‑SMAD2↓, 1,   p‑SMAD3↑, 1,   TGF-β↓, 2,   TGF-β1↓, 1,   TXNIP↓, 1,   VCAM-1↓, 1,   ZO-1↑, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   eNOS↑, 1,   Hif1a↓, 2,   NO↓, 3,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL18↓, 1,   IL1β↓, 4,   IL2↓, 1,   IL6↓, 3,   Imm↑, 1,   Inflam↓, 14,   JAK↓, 1,   mPGES-1↓, 1,   MyD88↓, 1,   NF-kB↓, 9,   PGE2↓, 3,   TLR4↓, 3,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 6,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 2,   BioAv↝, 3,   BioEnh↑, 1,   Dose?, 1,   Dose↓, 1,   Dose↝, 6,   eff↑, 1,   Half-Life↓, 1,   Half-Life↝, 1,   P450↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   AST↓, 5,   BloodF↑, 1,   BMD↑, 1,   BP↓, 2,   GutMicro↑, 4,   IL6↓, 3,   TG/TAG↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 6,   AntiCan↑, 2,   AntiDiabetic↑, 3,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 2,   hepatoP↑, 8,   memory↑, 2,   motorD↑, 1,   neuroP↑, 6,   NP/CIPN↓, 1,   Obesity↓, 3,   OS↑, 1,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 1,   Strength↑, 1,   toxicity↓, 3,   toxicity⇅, 1,   toxicity↝, 1,   toxicity∅, 2,   Weight↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 2,   Sepsis↓, 1,  
Total Targets: 204

Scientific Paper Hit Count for: AMPK, adenosine monophosphate-activated protein kinase
5 Resveratrol
3 Capsaicin
2 Berberine
2 Calorie Restriction Mimetics
2 EGCG (Epigallocatechin Gallate)
2 Emodin
2 Fisetin
2 itraconazole
2 Metformin
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Beta-Caryophyllene
1 Cannabidiol
1 bempedoic acid
1 Betulinic acid
1 Butyrate
1 Cichoric acid / Chicoric acid
1 HydroxyCitric Acid
1 Curcumin
1 Garcinol
1 Docosahexaenoic Acid
1 diet Short Term Fasting
1 Dandelion Root
1 Ginkgolic acids
1 isoorientin
1 isoquercitrin
1 Kaempferol
1 lambertianic acid
1 Licochalcone A
1 Luteolin
1 Lycopene
1 Methyl salicylate / Sweet Birch oil
1 Magnetic Field Rotating
1 Magnetic Fields
1 Rutin
1 buckwheat sprouts
1 Sulforaphane (mainly Broccoli)
1 Shikonin
1 Terminalia bellirica
1 Gallic acid
1 Urolithin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:9  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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