PGC1A Cancer Research Results

PGC1A, PPARγ Coactivator 1-alpha: Click to Expand ⟱
Source:
Type:
PPARγ Coactivator 1-alpha (PGC1A) is a transcriptional coactivator that plays a crucial role in regulating cellular energy metabolism, including glucose and lipid metabolism. In cancer, PGC1A has been implicated in the regulation of tumor cell metabolism, proliferation, and survival.

PGC1A is typically overexpressed and associated with poor prognosis and reduced overall survival in breast, lung, and colon cancers.
-PGC1A expression is also associated with increased risk of metastasis and recurrence in various types of cancer.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3222- EGCG,    Epigallocatechin gallate and mitochondria—A story of life and death
- Review, Nor, NA
*lipid-P↓, *SOD↑, *Catalase↑, GPx↑, *GR↑, *GSTs↑, *GSH↑, *SIRT1↑, *PGC1A↑, *other↑,
3012- RosA,  Rad,    Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p
- in-vitro, Nor, IMR90
*Inflam↓, *ROS↓, *p‑NF-kB↓, *Rho↓, *ROCK1↓, *radioP↑, *MCP1↓, *RANTES↓, *ICAM-1↓, *PGC1A↑, *NOX4↓, *Dose↝,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   NOX4↓, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

PGC1A↑, 2,   SIRT1↑, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

Rho↓, 1,   ROCK1↓, 1,  

Immune & Inflammatory Signaling ⓘ

ICAM-1↓, 1,   Inflam↓, 1,   MCP1↓, 1,   p‑NF-kB↓, 1,   RANTES↓, 1,  

Hormonal & Nuclear Receptors ⓘ

GR↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Functional Outcomes ⓘ

radioP↑, 1,  
Total Targets: 20

Scientific Paper Hit Count for: PGC1A, PPARγ Coactivator 1-alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:955  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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