GCLM Cancer Research Results

GCLM, Glutamate-Cysteine Ligase Modifier Subunit: Click to Expand ⟱

Source:

Type:

The GCLM gene (Glutamate-Cysteine Ligase Modifier Subunit) is a key regulator of glutathione synthesis, which is essential for maintaining cellular redox balance and protecting against oxidative stress. The GCLM gene is overexpressed in various types of cancer.

GCLM gene is a key regulator of glutathione synthesis and is overexpressed in various types of cancer. Its expression is associated with poor prognosis and increased risk of metastasis and recurrence.

Nor, Normal Healthy: Click to Expand ⟱

Normal Healthy

Scientific Papers found: Click to Expand⟱

3311-

SIL,

Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells

in-vitro,

Nor,

PC12

*antiOx↑, *Inflam↓, AntiCan↑, *ROS↓, *MDA↓, *GSH↓, *NRF2↑, *GPx↑, *GCLC↑, *GCLM↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Functional Outcomes ⓘ

AntiCan↑, 1,
Total Targets: 1

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 1, GCLC↑, 1, GCLM↑, 1, GPx↑, 1, GSH↓, 1, MDA↓, 1, NRF2↑, 1, ROS↓, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,
Total Targets: 9

Scientific Paper Hit Count for: GCLM, Glutamate-Cysteine Ligase Modifier Subunit

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells