GCLC Cancer Research Results

GCLC, Glutamate-Cysteine Ligase, Catalytic Subunit: Click to Expand ⟱
Source:
Type:
The GCLC gene (Glutamate-Cysteine Ligase, Catalytic Subunit) is a key regulator of glutathione synthesis, and its expression has been studied in various types of cancer.
GCLC gene has been found to be:
Amplified in 15% of breast cancer cases
Mutated in 5% of lung cancer cases
Deleted in 10% of prostate cancer cases
Methylated in 20% of colorectal cancer cases
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
3513- Bor,    Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Status
- in-vitro, Pca, DU145 - in-vitro, Nor, MEF
NRF2↑, selectivity↑, NQO1↑, GCLC↑, HO-1↑, TumCP↓,
7876- isoO,    Isoorientin exerts a protective effect against 6-OHDA-induced neurotoxicity by activating the AMPK/AKT/Nrf2 signalling pathway
- in-vitro, Nor, NA
*neuroP↑, *ROS↓, *MMP↑, *GCLC↑, *GCLM↑, *HO-1↑, *NQO1↑, *Trx1↑, *NRF2↑, *Keap1↓, *p‑AMPK↑, *p‑ERK↑, *p‑GSK‐3β↑, *p‑JNK↑, *p‑PI3K↑, *p‑Akt↑, *AMPK↑, *Akt↑,
8223- LCA,    Lico A Enhances Nrf2-Mediated Defense Mechanisms against t-BHP-Induced Oxidative Stress and Cell Death via Akt and ERK Activation in RAW 264.7 Cells
- in-vitro, Nor, RAW264.7
*Apoptosis↓, *ROS↓, *GSH↑, *GCLM↑, *GCLC↑, *HO-1↑, *NRF2↑, *Keap1↓, *ARE↑, *Akt↑, *ERK↑, *PI3K↑,
3311- SIL,    Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells
- in-vitro, Nor, PC12
*antiOx↑, *Inflam↓, AntiCan↑, *ROS↓, *MDA↓, *GSH↓, *NRF2↑, *GPx↑, *GCLC↑, *GCLM↑,
2225- SK,    Shikonin protects skin cells against oxidative stress and cellular dysfunction induced by fine particulate matter
- in-vitro, Nor, HaCaT
*antiOx↑, *ROS↓, *GSH↑, *GCLC↑, *GSS↑, *Akt↑, *NRF2↑,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GCLC↑, 1,   HO-1↑, 1,   NQO1↑, 1,   NRF2↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   ARE↑, 1,   GCLC↑, 4,   GCLM↑, 3,   GPx↑, 1,   GSH↓, 1,   GSH↑, 2,   GSS↑, 1,   HO-1↑, 2,   Keap1↓, 2,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 4,   ROS↓, 4,   Trx1↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   p‑AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 3,   p‑Akt↑, 1,   Apoptosis↓, 1,   p‑JNK↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   p‑ERK↑, 1,   p‑GSK‐3β↑, 1,   PI3K↑, 1,   p‑PI3K↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,  
Total Targets: 29

Scientific Paper Hit Count for: GCLC, Glutamate-Cysteine Ligase, Catalytic Subunit
1 Boron
1 isoorientin
1 Licochalcone A
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:966  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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