Dose Cancer Research Results

Dose, Dosage: Click to Expand ⟱
Source:
Type:
Drug dosage vs efficacy, and actual dosage number of research papers.
Nor, Normal Healthy: Click to Expand ⟱
Normal Healthy
Scientific Papers found: Click to Expand⟱
5307- 5-HTP,    5-Hydroxytryptophan toxicosis in dogs: 1989-1999
- Case Report, Nor, NA
*toxicity↝, *5HT↑, *Dose↝,
5457- AF,    Clinical pharmacokinetics of oral and injectable gold compounds
- Human, Nor, NA
*BioAv↝, *Dose↝, *Half-Life↑, *BioAv↝, *other↝,
5443- AG,    Pharmacokinetics and tolerance of toal astragalosides after intravenous infusion of astragalosides injection in healthy Chinese volunteers
- Human, Nor, NA
*Dose↝, Half-Life↝, *toxicity↓,
4402- AgNPs,    Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors
- in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-231 - in-vitro, Nor, MCF10
TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,
4400- AgNPs,  Rad,    Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells
- in-vitro, BC, MCF-7 - in-vitro, Nor, MCF10 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vivo, BC, MDA-MB-231
ROS↑, DNAdam↑, selectivity↑, TumCG↓, RadioS↑, Dose↝, selectivity↑, other↝, eff↓, eff↑, γH2AX↑, Dose↓, eff↑,
4447- AgNPs,    Anti-inflammatory action of silver nanoparticles in vivo: systematic review and meta-analysis
- Review, Nor, NA
*Inflam↓, *COX2↓, *ROS↓, *Dose↝, *eff↑, *toxicity↓, *IL4↑, *IL5↑, *IL10↑, *IL1↓, *IL6↓, *TNF-α↓, *NF-kB↓, *MDA↓, *GSH↑,
4598- AgNPs,    In vivo human time-exposure study of orally dosed commercial silver nanoparticles
- in-vivo, Nor, NA
*toxicity∅, *Dose↝, *Dose↝, *BioAv↝, *BioAv↝, *H2O2∅, *IL8∅, *IL1α∅, *IL1β∅, *MCP1∅, *NQO1∅, *BioAv↓,
2206- AgNPs,  RES,    ENHANCED EFFICACY OF RESVERATROL-LOADED SILVER NANOPARTICLE IN ATTENUATING SEPSIS-INDUCED ACUTE LIVER INJURY: MODULATION OF INFLAMMATION, OXIDATIVE STRESS, AND SIRT1 ACTIVATION
- in-vivo, Nor, NA
*hepatoP↑, *Inflam↓, *NF-kB↓, *VEGF↓, *SIRT1↑, *ROS↓, *Dose↝, *Catalase↑, *MDA↓, *MPO↓, *NO↓, *ALAT↓, *AST↓, *antiOx↑,
2205- AgNPs,    Potential protective efficacy of biogenic silver nanoparticles synthesised from earthworm extract in a septic mice model
- in-vivo, Nor, NA
*Dose↝, *eff↑, *RenoP↑, *antiOx↑, *MDA↓, *NO↓, *hepatoP↑, *toxicity↝, *GSH↑, *SOD↑, *GSTs↑, *Catalase↑,
5353- AL,    Aged Garlic Extract May Be Safe for Patients on Warfarin Therapy
- Human, Nor, NA
*AntiAg↑, *toxicity↓, *cardioP↑, *Dose↝,
2560- AL,    Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease
- ex-vivo, Nor, NA
*AntiAg↑, BioAv↝, Dose↝,
2569- ART/DHA,    A semiphysiological pharmacokinetic model for artemisinin in healthy subjects incorporating autoinduction of metabolism and saturable first-pass hepatic extraction
- Human, Nor, NA
*Half-Life↝, BioAv↝, *Half-Life↓, BioAv↑, *Dose↝,
5417- ASTX,    Comparative Pharmacokinetic Study of Standard Astaxanthin and its Micellar Formulation in Healthy Male Volunteers
- Study, Nor, NA
*antiOx↑, *BioAv↓, *Dose↝, *BioAv↑,
5445- ATV,    Atorvastatin
- NA, Nor, NA
*cardioP↑, *LDL↓, HMG-CoA↓, Half-Life↝, BioAv↓, Dose↝,
5572- B-Gluc,    The Effects of Orally Administered Beta-Glucan on Innate Immune Responses in Humans, a Randomized Open-Label Intervention Pilot-Study
- Study, Nor, NA
Imm↑, *Dose↝, *BioAv↓, *toxicity↑,
5500- Ba,    Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single‐center, randomized, double‐blind, placebo‐controlled multiple‐ascending‐dose study
- Trial, Nor, NA
*toxicity↓, *BioAv↑, *Half-Life↝, *Dose↝,
2689- BBR,    Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
- in-vitro, Nor, PC12 - in-vitro, AD, NA - in-vitro, Stroke, NA
*ROS↓, *lipid-P↓, *DNAdam↓, *GSH↑, *SOD↑, *eff↑, *cl‑Casp3↓, *BAX↓, *neuroP↑, *Dose↝, *Ca+2↓,
5514- bemA,    Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients
- Trial, Nor, NA
*ACLY↓, *LDL↓, *MusCon↓, Dose↝, cardioP↑,
5557- betaCar,    The Effect of Beta-Carotene on Cognitive Function: A Systematic Review
- Review, Nor, NA
*antiOx↑, *cognitive↑, *Dose↝, *eff↑,
5650- BNL,    Borneol Depresses P-Glycoprotein Function by a NF-κB Signaling Mediated Mechanism in a Blood Brain Barrier in Vitro Model
- in-vivo, Nor, NA
*P-gp↓, *NF-kB↑, *eff↓, *Dose↝,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
5879- CAR,    Pharmacokinetic analysis of thymol, carvacrol and diallyl disulfide after intramammary and topical applications in healthy organic dairy cattle
- in-vivo, Nor, NA
*Dose↝, Half-Life↝, Half-Life↝, Half-Life↝,
5883- CAR,    Safety and tolerability of carvacrol in healthy subjects: a phase I clinical study
- Trial, Nor, NA
*Dose↝, *HDL↓, *Bil↓, *Iron↓, *toxicity↓,
5881- CAR,    Carvacrol—A Natural Phenolic Compound with Antimicrobial Properties
- Review, Nor, NA
*Bacteria↓, *Inflam↓, *SOD↑, *GPx↑, *GSR↑, *Catalase↑, *toxicity↓, *Pain↓, *other↑, *cardioP↑, *RenoP↑, *neuroP↑, *antiOx↑, *AntiDiabetic↑, *hepatoP↑, *Obesity↓, *AntiAg↑, *BioAv↓, BioAv↝, *OS↑, MMP↓, ROS↑, *MDA↓, *lipid-P↓, *COX2↓, *Dose↝,
5880- CAR,    In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis
- vitro+vivo, Lung, A549 - in-vitro, Nor, BEAS-2B - in-vitro, Lung, PC9
Dose↝, mt-ROS↑, p‑JNK↑, BAX↑, Cyt‑c↑, Casp↑, AntiTum↑, ER Stress↑, LDH↑, selectivity↑, Apoptosis↑, DNAdam↑, IRE1↑, XBP-1↑, CHOP↓, p‑eIF2α↓, GRP78/BiP↓, Ca+2↑, MMP↓, Bcl-2↓, Casp3↑, Casp9↑, eff↓, TumW↓, Weight↑, eff↑, eff↑,
5908- CAR,    Carvacrol improves neurological function by inhibiting TRPM7-mediated BBB disruption and hemorrhage after TBI
- in-vivo, Nor, NA
*TRPM7↓, *BBB↑, *motorD↑, *cognitive↑, *Dose↝, MMPs↓,
5889- CAR,    Effect of carvacrol on pulmonary function tests, and total and differential white blood cell counts in healthy volunteers: A randomized clinical trial
- Trial, Nor, NA
*Dose↝, *toxicity∅,
6022- CGA,    Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome
- Review, Nor, NA
*antiOx↑, *Inflam↓, *AntiDiabetic↑, *Obesity↓, *Wound Healing↑, *BP↓, *Dose↝, *ROS↓, *Fas↓, *HMG-CoA↓, *GutMicro↑,
6035- CGA,    Effect of Chlorogenic Acids on Cognitive Function in Mild Cognitive Impairment: A Randomized Controlled Crossover Trial
- Trial, Nor, NA
*Dose↝, *cognitive↑, *Risk↓, *AChE↓, *ROS↓,
6029- CGA,    Pharmacokinetics of chlorogenic acids absorbed in human plasma and their metabolites following oral ingestion of coffee drink
- Trial, Nor, NA
*Dose↝, *BioAv↑, *Half-Life↝,
6028- CGA,    Chlorogenic acids from green coffee extract are highly bioavailable in humans
- Trial, Nor, NA
*BioAv↑, *Dose↝,
6089- CHOC,    Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial
- Trial, Nor, NA
*Dose↝, *BP↓, *cognitive↑,
6087- CHOC,    Effect of cocoa flavanol supplementation for the prevention of cardiovascular disease events: the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized clinical trial
- Trial, Nor, NA
*cardioP↑, *Dose↝, *BP↓, *Inflam↓, *AntiAg↑, *Risk↓,
6090- CHOC,    Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
- Review, Nor, NA
*Dose↝, *cardioP↑,
6101- Chol,    Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-N-Oxide Response in Healthy Men
- Human, Nor, NA
*TMAO↑, *Dose↝, *GutMicro↝,
6098- Chol,    Choline
- Review, Nor, NA - Review, AD, NA
*BioAv↝, *Dose↝, *cardioP↑, *BP↓, *cognitive↑, *memory↑, eff∅,
6108- Chol,    Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health
- Review, Nor, NA - Review, AD, NA
*TMAO↑, *ROS↑, *NADPH↑, *Ca+2↑, *AntiAg↓, *cognitive↓, *TJ↓, *CLDN1↓, *ZO-1↓, *Inflam↑, *NLRP3↑, *ER Stress↑, *cognitive↓, *Dose↝, *eff↑, *other↝, *other↝, *other↝,
5791- CRMs,  HCA,  NAD,  Sper,  RES  Caloric Restriction Mimetics in Nutrition and Clinical Trials
- Review, Nor, NA
*Dose↝, *Glycolysis↓,
5798- CRMs,    Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders
- Review, Nor, NA - Review, AD, NA
*GutMicro↑, *neuroP↑, *eff↑, *Dose↝, *AMPK↑, *SIRT1↑, *mTOR↓, *NRF2↑, *p‑tau↓,
2304- CUR,    Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition
- in-vitro, Lung, H1299 - in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Pca, PC3 - in-vitro, Nor, HEK293
Glycolysis↓, GlucoseCon↓, lactateProd↓, PKM2↓, mTOR↓, Hif1a↓, selectivity↑, Dose↝, tumCV↓,
3245- EGCG,    (−)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway
- in-vitro, Nor, PC12
*neuroP↑, *Shh↑, *Gli1↑, *n-MYC↑, *Dose↝,
5227- EMD,    Emodin and emodin-rich rhubarb inhibits histone deacetylase (HDAC) activity and cardiac myocyte hypertrophy
- vitro+vivo, Nor, NA
*cardioP↑, HDAC↓, HDAC1↓, HDAC2↓, ac‑H3↑, Dose↝, BioAv↓,
5523- EP,    Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication
- vitro+vivo, Nor, HUVECs
*MMP↑, *Hif1a↑, *SIRT1↑, *ROS↓, *AntiAge↑, *Dose↝, *angioG↑,
5230- Ex,    Effects of an acute maximal exercise bout on serum insulin-like growth factor-1 in adults with MDD
- Trial, Nor, NA
*IGF-1↑, Dose↝,
3152- H2,  VitC,  Rad,    Hydrogen and Vitamin C Combination Therapy: A Novel Method of Radioprotection
- in-vitro, Nor, HUVECs - in-vivo, NA, NA
AntiTum↑, OS↑, QoL↑, TumVol↓, radioP↑, Dose↑, Dose↝, eff↑,
4005- K+,    Potassium
- Review, Nor, NA - Review, Stroke, NA
*Risk↓, *Dose↝, *Risk↓, *BMD↑, *glucose↓,
1713- Lyco,    Lycopene: A Potent Antioxidant with Multiple Health Benefits
- Review, Nor, NA
*antiOx↑, *ROS⇅, *Dose↝, *eff↑, *LDL↓, *RenoP↑, *Inflam↓, neuroP↑, Rho↓,
2644- MCT,    The Effects of Medium-Chain Triglyceride Oil Supplementation on Endurance Performance and Substrate Utilization in Healthy Populations: A Systematic Review
- Review, Nor, NA
*KeyT↑, *Dose↝, eff↑,
4015- MF,    Evaluation of the PTEN and circRNA-CDR1as Gene Expression Changes in Gastric Cancer and Normal Cell Lines Following the Exposure to Weak and Moderate 50 Hz Electromagnetic Fields
- in-vitro, GC, AGS - in-vitro, Nor, HU02
*PTEN↑, PTEN↓, Dose↝,
5533- MF,    Magnetic field-induced drug permeability in liposome vesicles
- in-vitro, Nor, NA
*Dose↝, *CellMemb↑, *other↝,

Showing Research Papers: 1 to 50 of 76
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 76

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   compI↓, 1,   GPx↓, 1,   GSH↓, 1,   GSH/GSSG↓, 1,   ROS↑, 3,   mt-ROS↑, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   compIII↓, 1,   MMP↓, 3,  

Core Metabolism/Glycolysis ⓘ

GlucoseCon↓, 1,   Glycolysis↓, 1,   HMG-CoA↓, 1,   lactateProd↓, 1,   LDH↑, 1,   PKM2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp↑, 1,   Casp3↑, 2,   Casp9↑, 2,   Cyt‑c↑, 2,   p‑JNK↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

ac‑H3↑, 1,   other↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↓, 1,   p‑eIF2α↓, 1,   ER Stress↑, 1,   GRP78/BiP↓, 1,   IRE1↑, 1,   XBP-1↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   γH2AX↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,   mTOR↓, 1,   PTEN↓, 1,   TumCG↓, 1,  

Migration ⓘ

Ca+2↑, 1,   MMPs↓, 1,   Rho↓, 1,  

Angiogenesis & Vasculature ⓘ

Hif1a↓, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 3,   Dose↓, 1,   Dose↑, 1,   Dose↝, 12,   eff↓, 2,   eff↑, 7,   eff∅, 1,   Half-Life↝, 5,   RadioS↑, 1,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

LDH↑, 1,  

Functional Outcomes ⓘ

AntiTum↑, 2,   cardioP↑, 1,   neuroP↑, 1,   OS↑, 2,   QoL↑, 1,   radioP↑, 1,   TumVol↓, 1,   TumW↓, 1,   Weight↑, 1,  
Total Targets: 70

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

TMAO↑, 2,  

Redox & Oxidative Stress ⓘ

antiOx↑, 7,   Bil↓, 1,   Catalase↑, 3,   GPx↑, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 1,   H2O2∅, 1,   HDL↓, 1,   Iron↓, 1,   lipid-P↓, 2,   MDA↓, 4,   MPO↓, 1,   NQO1∅, 1,   NRF2↑, 1,   ROS↓, 6,   ROS↑, 1,   ROS⇅, 1,   ROS∅, 1,   SOD↑, 3,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACLY↓, 1,   ALAT↓, 1,   AMPK↑, 1,   glucose↓, 1,   Glycolysis↓, 1,   HMG-CoA↓, 1,   KeyT↑, 1,   LDL↓, 3,   NADPH↑, 1,   SIRT1↑, 3,  

Cell Death ⓘ

BAX↓, 1,   cl‑Casp3↓, 1,   Fas↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,   other↝, 5,  

Protein Folding & ER Stress ⓘ

ER Stress↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

Gli1↑, 1,   IGF-1↑, 1,   mTOR↓, 1,   n-MYC↑, 1,   PTEN↑, 1,   Shh↑, 1,   TRPM7↓, 1,  

Migration ⓘ

AntiAg↓, 1,   AntiAg↑, 4,   Ca+2↓, 1,   Ca+2↑, 1,   CLDN1↓, 1,   TJ↓, 1,   ZO-1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,   Hif1a↑, 1,   NO↓, 2,   VEGF↓, 1,  

Barriers & Transport ⓘ

BBB↑, 1,   CellMemb↑, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   IL1↓, 1,   IL10↑, 1,   IL1α∅, 1,   IL1β∅, 1,   IL4↑, 1,   IL5↑, 1,   IL6↓, 1,   IL8∅, 1,   Inflam↓, 6,   Inflam↑, 1,   MCP1∅, 1,   NF-kB↓, 2,   NF-kB↑, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

5HT↑, 1,   AChE↓, 1,   p‑tau↓, 1,  

Protein Aggregation ⓘ

NLRP3↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 4,   BioAv↝, 5,   Dose↝, 39,   eff↓, 1,   eff↑, 7,   Half-Life↓, 1,   Half-Life↑, 1,   Half-Life↝, 3,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AST↓, 1,   Bil↓, 1,   BMD↑, 1,   BP↓, 4,   GutMicro↑, 2,   GutMicro↝, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 7,   cognitive↓, 2,   cognitive↑, 5,   hepatoP↑, 3,   memory↑, 1,   motorD↑, 1,   MusCon↓, 1,   neuroP↑, 4,   Obesity↓, 2,   OS↑, 1,   Pain↓, 1,   RenoP↑, 3,   Risk↓, 4,   toxicity↓, 6,   toxicity↑, 1,   toxicity↝, 3,   toxicity∅, 3,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 117

Scientific Paper Hit Count for: Dose, Dosage
7 Silver-NanoParticles
7 Carvacrol
6 Radiotherapy/Radiation
5 Chlorogenic acid
5 Selenium NanoParticles
4 Resveratrol
4 nicotinamide adenine dinucleotide
3 Chocolate
3 Choline
3 Vitamin C (Ascorbic Acid)
3 Magnetic Fields
2 Allicin (mainly Garlic)
2 Calorie Restriction Mimetics
2 Spermidine
2 Selenium
2 Shikonin
2 Vitamin K2
1 5-Hydroxytryptophan
1 Auranofin
1 Astragalus
1 Artemisinin
1 Astaxanthin
1 Atorvastatin
1 beta-glucans
1 Baicalein
1 Berberine
1 bempedoic acid
1 beta-carotene(VitA)
1 borneol
1 Capsaicin
1 HydroxyCitric Acid
1 Curcumin
1 EGCG (Epigallocatechin Gallate)
1 Emodin
1 Electrical Pulses
1 Exercise
1 Hydrogen Gas
1 Potassium
1 Lycopene
1 MCToil
1 Magnetic Field Rotating
1 Methylsulfonylmethane
1 Niclosamide (Niclocide)
1 Phenethyl isothiocyanate
1 Rosmarinic acid
1 chitosan
1 Selenite (Sodium)
1 Thymol-Thymus vulgaris
1 Vitamin D3
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:49  Cells:%  prod#:%  Target#:1114  State#:%  Dir#:4
  wNotes=0  sortOrder:rid,rpid

 

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