CaMKII Cancer Research Results

CaMKII , Calcium/Calmodulin-dependent Protein Kinase II: Click to Expand ⟱

Source:

Type:

CaMKII, short for Calcium/Calmodulin-dependent Protein Kinase II, is not a single protein but rather a family of related enzymes composed of several isoforms.
Breakdown:
CaMKII Isoforms:4 genes encoding the major isoforms: α(alpha), β(beta), γ(gamma), and δ(delta). CaMKIIα and CaMKIIβ are abundant in neuronal tissue, while CaMKIIδ is more prevalent in the heart and other non-neuronal tissues.

-Overexpression or hyperactivation of CaMKII has been linked in some studies to enhanced cell cycle progression and resistance to apoptosis, both of which are features of more aggressive tumors.
-In some cancers, upregulation or increased activity of CaMKII has been associated with poor clinical outcomes, including lower overall survival or higher recurrence rates.

CLL, Chronic Lymphocytic Leukemia: Click to Expand ⟱

CLL is a type of cancer that affects the lymphoid cells, which are a type of white blood cell. It is characterized by the accumulation of mature, but dysfunctional, lymphocytes in the bone marrow, lymph nodes, and spleen. CLL is typically a slow-growing disease, and many patients may not experience symptoms for years after diagnosis.

Scientific Papers found: Click to Expand⟱

5537-

BBM,

CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine

in-vitro,

CLL,

CaMKII ↓, NF-kB↓, IKKα↓, p‑STAT3↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Kinase & Signal Transduction ⓘ

CaMKII ↓, 1,

Proliferation, Differentiation & Cell State ⓘ

p‑STAT3↓, 1,

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1, NF-kB↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CaMKII , Calcium/Calmodulin-dependent Protein Kinase II

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells