Mcl-1 Cancer Research Results

Mcl-1, myeloid cell leukemia 1: Click to Expand ⟱

Source: HalifaxProj(inhibit)

Type:

A member of the Bcl-2 family of proteins, which play a crucial role in regulating apoptosis, or programmed cell death. In cancer, Mcl-1 is often overexpressed, contributing to the development and progression of various types of tumors.
Mcl-1 is often overexpressed in several cancers, including hematological malignancies (like leukemia and lymphoma) and solid tumors (such as breast, lung, and prostate cancers).
Mcl-1 inhibits apoptosis by binding to pro-apoptotic proteins, preventing them from triggering the cell death pathway.

CLL, Chronic Lymphocytic Leukemia: Click to Expand ⟱

CLL is a type of cancer that affects the lymphoid cells, which are a type of white blood cell. It is characterized by the accumulation of mature, but dysfunctional, lymphocytes in the bone marrow, lymph nodes, and spleen. CLL is typically a slow-growing disease, and many patients may not experience symptoms for years after diagnosis.

Scientific Papers found: Click to Expand⟱

4953-

PEITC,

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

in-vitro,

CLL,

 4-8 µM

ROS↑, GSH↓, TumCD↓, eff↓, Mcl-1↓, Casp3↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GSH↓, 1, ROS↑, 1,

Cell Death ⓘ

Casp3↑, 1, Mcl-1↓, 1, TumCD↓, 1,

Drug Metabolism & Resistance ⓘ

eff↓, 1,
Total Targets: 6

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: Mcl-1, myeloid cell leukemia 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells