JAK2 Cancer Research Results
JAK2, Janus kinase 2: Click to Expand ⟱
| Source: CGL-Driver Genes |
| Type: Oncogene |
A tyrosine kinase that plays a crucial role in the signaling pathways of various cytokines and growth factors. It is particularly important in hematopoiesis (the formation of blood cells) and immune responses.
JAK2 plays a significant role in cancer biology, particularly in hematological malignancies, where its expression and activity are often upregulated. Increased JAK2 activity is generally associated with worse prognosis in many cancers, indicating its potential role in promoting tumor growth and survival.
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EC, Endometrial Cancer: Click to Expand ⟱
Endometrial cancer (EC) is the most common gynecological cancer, and one of the most important causes of cancer-related deaths in women worldwide.
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Scientific Papers found: Click to Expand⟱
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in-vitro, |
EC, |
EMN8 |
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in-vitro, |
EC, |
EMN21 |
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CSCs↓, ALDH1A1↓, cMyc↓, Nanog↓, OCT4↓, STAT3↓, JAK2↓, STAT3↓, eff↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Core Metabolism/Glycolysis ⓘ
cMyc↓, 1,
Proliferation, Differentiation & Cell State ⓘ
ALDH1A1↓, 1, CSCs↓, 1, Nanog↓, 1, OCT4↓, 1, STAT3↓, 2,
Immune & Inflammatory Signaling ⓘ
JAK2↓, 1,
Drug Metabolism & Resistance ⓘ
eff↑, 1,
Total Targets: 8
Pathway results for Effect on Normal Cells:
Total Targets: 0
Scientific Paper Hit Count for: JAK2, Janus kinase 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:52 Cells:% prod#:% Target#:164 State#:% Dir#:1
wNotes=0 sortOrder:rid,rpid
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