Ferroptosis Cancer Research Results

Ferroptosis, Ferroptosis: Click to Expand ⟱
Source:
Type: type of cell death
Type of programmed cell death dependent on iron.
Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid peroxides to lethal levels. It is distinct from other forms of cell death, such as apoptosis, necrosis, and autophagy. The process of ferroptosis is heavily dependent on iron metabolism and reactive oxygen species (ROS).
The accumulation of lipid peroxides is a hallmark of ferroptosis. This can occur when the antioxidant defenses, such as glutathione and selenoproteins, are overwhelmed or inhibited. Many cancer cells upregulate GPX4 to evade ferroptosis, making it a potential target for therapy. It has been described that GPX4, xCT and ACSL-4 are the main targets in the regulation of ferroptosis.
Col, Colitis: Click to Expand ⟱
Colitis is an inflammation of the inner lining of the colon (large intestine). This condition can cause symptoms such as abdominal pain, diarrhea (often with blood or pus), fatigue, and sometimes weight loss. There are various types of colitis, including:

Ulcerative colitis: A chronic condition that causes long-lasting inflammation and ulcers in the digestive tract, primarily affecting the lining of the large intestine and rectum.
Infectious colitis: Caused by bacteria, viruses, or parasites, leading to temporary inflammation.
Ischemic colitis: Occurs when blood flow to a section of the colon is reduced, resulting in inflammation and damage to the colon tissue.
Microscopic colitis: Includes conditions like collagenous colitis and lymphocytic colitis, which are characterized by inflammation that can only be seen under a microscope.
Scientific Papers found: Click to Expand⟱
4727- SSE,    Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4
- in-vivo, Col, NA
*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Functional Outcomes ⓘ

AntiTum↑, 1,  
Total Targets: 1

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Ferroptosis↓, 1,   GPx4↑, 1,   NRF2↑, 1,  

Cell Death ⓘ

Ferroptosis↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: Ferroptosis, Ferroptosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:53  Cells:%  prod#:%  Target#:114  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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