LDHA Cancer Research Results

LDHA, Lactate dehydrogenase A: Click to Expand ⟱
Source:
Type:
LDHA is a key enzyme that catalyzes the conversion of pyruvate into lactate while regenerating NAD+, essential for glycolysis.
Elevated levels of LDHA have been associated with increased tumor growth and survival. By promoting lactate production, cancer cells can create an acidic microenvironment that may facilitate invasion and metastasis.
Is often upregulated in various types of cancer, including breast, lung, colorectal, and prostate cancers. This upregulation is associated with the metabolic shift that cancer cells undergo to support rapid growth and proliferation.
Measuring the lactate dehydrogenase (LDH) is a useful method for detection of necrosis.
Col, Colitis: Click to Expand ⟱
Colitis is an inflammation of the inner lining of the colon (large intestine). This condition can cause symptoms such as abdominal pain, diarrhea (often with blood or pus), fatigue, and sometimes weight loss. There are various types of colitis, including:

Ulcerative colitis: A chronic condition that causes long-lasting inflammation and ulcers in the digestive tract, primarily affecting the lining of the large intestine and rectum.
Infectious colitis: Caused by bacteria, viruses, or parasites, leading to temporary inflammation.
Ischemic colitis: Occurs when blood flow to a section of the colon is reduced, resulting in inflammation and damage to the colon tissue.
Microscopic colitis: Includes conditions like collagenous colitis and lymphocytic colitis, which are characterized by inflammation that can only be seen under a microscope.
Scientific Papers found: Click to Expand⟱
2398- CGA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- in-vivo, Col, NA
PKM2↓, Glycolysis↓, NLRP3↓, Inflam↓, HK2↓, PDK1↓, LDHA↓, GLUT1↓, ECAR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PDK1↓, 1,   PKM2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LDHA, Lactate dehydrogenase A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:53  Cells:%  prod#:%  Target#:175  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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