ECAR Cancer Research Results

ECAR, Extracellular Acidification Rate: Click to Expand ⟱
Source:
Type:
ECAR (Extracellular Acidification Rate) is a measure of the rate at which cells release acidic byproducts, such as lactic acid, into the extracellular environment. In the context of cancer, ECAR is often used as a proxy for glycolytic activity, as cancer cells often exhibit increased glycolysis, even in the presence of oxygen.

Studies have shown that cancer cells often have a higher ECAR compared to normal cells, indicating that they are producing more acidic byproducts. This is thought to be due to the fact that cancer cells often rely more heavily on glycolysis for energy production, even in the presence of oxygen.
-ECAR reflects the glycolysis activity
Col, Colitis: Click to Expand ⟱
Colitis is an inflammation of the inner lining of the colon (large intestine). This condition can cause symptoms such as abdominal pain, diarrhea (often with blood or pus), fatigue, and sometimes weight loss. There are various types of colitis, including:

Ulcerative colitis: A chronic condition that causes long-lasting inflammation and ulcers in the digestive tract, primarily affecting the lining of the large intestine and rectum.
Infectious colitis: Caused by bacteria, viruses, or parasites, leading to temporary inflammation.
Ischemic colitis: Occurs when blood flow to a section of the colon is reduced, resulting in inflammation and damage to the colon tissue.
Microscopic colitis: Includes conditions like collagenous colitis and lymphocytic colitis, which are characterized by inflammation that can only be seen under a microscope.
Scientific Papers found: Click to Expand⟱
2398- CGA,    Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation
- in-vivo, Col, NA
PKM2↓, Glycolysis↓, NLRP3↓, Inflam↓, HK2↓, PDK1↓, LDHA↓, GLUT1↓, ECAR↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

ECAR↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PDK1↓, 1,   PKM2↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ECAR, Extracellular Acidification Rate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:53  Cells:%  prod#:%  Target#:847  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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