mTOR Cancer Research Results

mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Endo, Endometriosis: Click to Expand ⟱
Endometriosis is a condition in which tissue similar to the uterine lining grows outside the uterus, causing pain and sometimes infertility.
Scientific Papers found: Click to Expand⟱
8019- itraC,    Itraconazole Inhibits AKT/mTOR Signaling and Proliferation in Endometrial Cancer Cells
- in-vitro, Endo, AN3CA - in-vitro, Endo, HEC-1A - in-vitro, Endo, HEC-50B - in-vitro, Endo, SNG-II
*AntiFungal↑, TumCP↓, mTOR↓, LC3II↑, TumAuto↑, Akt↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3II↑, 1,   TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,  
Total Targets: 1

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:57  Cells:%  prod#:%  Target#:209  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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