PSEN2/PS-2 Cancer Research Results

PSEN2/PS-2, Presenilin 2: Click to Expand ⟱
Source:
Type:

PSEN2 - Presenilin 2

Type: Intramembrane aspartyl protease / catalytic γ-secretase complex subunit

Function: PSEN2 is a catalytic component of the γ-secretase complex, together with nicastrin, APH1, and PEN2. The complex performs intramembrane proteolysis of multiple substrates including amyloid precursor protein (APP) and Notch receptors. γ-Secretase cleavage of APP generates amyloid-β peptides including Aβ40 and Aβ42. PSEN2 also participates in endolysosomal, calcium, mitochondrial, and cellular signaling functions.

Alzheimer's Disease: ↕ Altered function. Pathogenic PSEN2 mutations cause rare autosomal-dominant familial Alzheimer's disease by altering γ-secretase processing of APP. Many disease-associated mutations increase the relative production of aggregation-prone Aβ42, producing an increased Aβ42/Aβ40 ratio. The primary Alzheimer's mechanism therefore reflects altered PSEN2/γ-secretase activity rather than a consistent increase or decrease in PSEN2 expression.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
7801- IBC,    Isobavachalcone as an Active Membrane Perturbing Agent and Inhibitor of ABCB1 Multidrug Transporter
- in-vitro, CRC, HT-29
PSEN2/PS-2↓, AntiCan↑, Apoptosis↑, Akt↓, ERK↓, *antiOx↑, *Inflam↓, *neuroP↑, *toxicity↓, selectivity↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

PSEN2/PS-2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: PSEN2/PS-2, Presenilin 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:1699  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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