PGE2 Cancer Research Results

PGE2, Prostaglandin E2: Click to Expand ⟱
Source:
Type:
Prostaglandin E2 (PGE2) is a lipid compound that plays a significant role in various physiological processes, including inflammation, immune response, and regulation of cell growth. PGE2 is often found at elevated levels in various types of cancer, including colorectal, breast, and lung cancers. It can promote tumor growth by enhancing cell proliferation, inhibiting apoptosis (programmed cell death), and promoting angiogenesis (the formation of new blood vessels).
- PGE2 is a pain-inducing factor. It is able to sensitize primary sensory neurons and leads to central sensitization and also facilitate the release of pain-related neuropeptides
-Upregulated in AD brain; promotes inflammatory cytokine release, increase ROS, may increase Aβ deposition
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
6607- Ech,    Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines
- in-vitro, PC, MIA PaCa-2 - in-vitro, CRC, Colo320
tumCV↓, eff↑, Apoptosis↑, Casp3↑, Casp7↑, DNAdam↑, Imm↑, NK cell↑, PGE2↓, COX1↓, COX2/PTGS2↓, 5LO↓,
811- GAR,    Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells
- in-vitro, CRC, HT-29
mPGES-1↓, Hif1a↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, Casp3↑, TumCP↓, PGE2↓,
7641- Ins,    Overview of Inositol and Inositol Phosphates on Chemoprevention of Colitis-Induced Carcinogenesis
- Review, CRC, NA
AntiCan↑, p‑Akt↓, TF-Ag↓, *PI3K↓, *AP-1↓, *DNArepair↑, *BioAv↑, *BBB↑, *other↑, *PGE2↓,
1019- TQ,    Thymoquinone suppresses migration of LoVo human colon cancer cells by reducing prostaglandin E2 induced COX-2 activation
- vitro+vivo, CRC, LoVo
TumCP↓, p‑PI3K↓, p‑Akt↓, p‑GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, PGE2↓, EP2↓, EP4/PTGER4↓,
3397- TQ,    Thymoquinone: A Promising Therapeutic Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
ChemoSen↑, *Half-Life↝, *BioAv↝, *antiOx↑, *Inflam↓, *hepatoP↑, TumCP↓, TumCCA↑, Apoptosis↑, angioG↑, selectivity↑, JNK↑, p38↑, p‑NF-kB↑, ERK↓, PI3K↓, PTEN↑, Akt↓, mTOR↓, EMT↓, Twist↓, E-cadherin↓, ROS⇅, *Catalase↑, *SOD↑, *GSTA1↑, *GPx↑, *PGE2↓, *IL1β↓, *COX2/PTGS2↓, *MMP13↓, MMPs↓, TumMeta↓, VEGF↓, STAT3↓, BAX↑, Bcl-2↑, Casp9↑, Casp7↑, Casp3↑, cl‑PARP↑, survivin↓, cMyc↓, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, GSK‐3β↓, β-catenin/ZEB1↓, chemoP↑,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

TF-Ag↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS⇅, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↝, 1,   cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↓, 2,   Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↑, 1,   Casp3↑, 3,   Casp7↑, 2,   Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 1,   JNK↑, 1,   p27/CDKN1B↑, 1,   p38↑, 1,   survivin↓, 1,   Telomerase↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

GRP78/BiP↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   cycD1/CCND1↓, 2,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 2,   EP2↓, 1,   EP4/PTGER4↓, 1,   ERK↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   mTOR↓, 1,   mTOR↝, 1,   PI3K↓, 1,   p‑PI3K↓, 1,   PTEN↑, 1,   STAT3↓, 1,   p‑STAT3↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   E-cadherin↓, 2,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 2,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 3,   TumMeta↓, 1,   Twist↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 3,   CXCR4↓, 1,   Imm↑, 1,   p‑JAK2↓, 1,   mPGES-1↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   PGE2↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   eff↑, 1,   eff↝, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   GutMicro↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 1,  
Total Targets: 75

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   GSTA1↑, 1,   SOD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNArepair↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   MMP13↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   Inflam↓, 2,   PGE2↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,   Half-Life↝, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 23

Scientific Paper Hit Count for: PGE2, Prostaglandin E2
2 Thymoquinone
1 Berberine
1 Echinacea
1 Garcinol
1 Inositol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:248  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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