TumPF Cancer Research Results

TumPF, Tumor-promoting fibroblasts: Click to Expand ⟱
Source: HalifaxProj(deactivate)
Type:
Tumor-promoting fibroblasts, often referred to as cancer-associated fibroblasts (CAFs), play a significant role in the tumor microenvironment and contribute to cancer progression.
CAFs are derived from various sources, including resident fibroblasts, mesenchymal stem cells, and even epithelial cells through a process called epithelial-to-mesenchymal transition (EMT). They exhibit distinct characteristics compared to normal fibroblasts, including altered gene expression and increased secretion of growth factors and cytokines.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MMP2↓, MMP9↓, miR-34a↑, miR-25-5p↑, miR-195↑, miR-27a-3p↑, Let-7↑, miR-106b↓, miR-17↓, miR-21↓, miR-155↓, miR-221↓, TumPF↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-106b↓, 1,   miR-195↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

miR-25-5p↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   miR-27a-3p↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↑, 1,   miR-34a↑, 1,  

Migration(tgid=13) ⓘ

miR-155↓, 1,   miR-221↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumPF↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

miR-17↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TumPF, Tumor-promoting fibroblasts
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:329  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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