cDC2 Cancer Research Results

cDC2, type 2 conventional dendritic cell: Click to Expand ⟱
Source:
Type:
Play an important role in antitumor immunity by promoting cytotoxic T-cell responses and helper T-cell differentiation.
Dendritic cells (DCs) consist of three major subsets termed plasmacytoid (pDCs), type-1 (cDC1s), and type-2 (cDC2s) conventional (or classical) DCs.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
8207- LCA,    Licochalcone a Induces ROS-Mediated Apoptosis through TrxR1 Inactivation in Colorectal Cancer Cells
- in-vitro, CRC, HCT116
ROS↑, TumCCA↑, Apoptosis↑, eff↓, TrxR1↓, cDC2↓, Bcl-2↓, BAX↑, NRF2↓, p‑ASK1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   ROS↑, 1,   TrxR1↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   p‑ASK1↑, 1,   BAX↑, 1,   Bcl-2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cDC2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cDC2, type 2 conventional dendritic cell
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:439  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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