S6K Cancer Research Results

S6K, S6 kinase: Click to Expand ⟱
Source:
Type: protein
S6K (S6 kinase) is a protein that plays a crucial role in cell growth, proliferation, and survival. It is a downstream target of the mTOR (mechanistic target of rapamycin) signaling pathway, which is a central regulator of cellular metabolism, growth, and division.

Research has shown that S6K is involved in the development and progression of various types of cancer, including breast, lung, prostate, and colon cancer. Overexpression or hyperactivation of S6K has been observed in many cancer types.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
445- CUR,    Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway
- in-vitro, CRC, HCT116 - in-vitro, CRC, HCT8 - in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
p‑AMPK↑, p‑ACC-α↑, NBR2↑, p‑S6K↓, mTOR↓,
7642- IP6,    Inositol Hexaphosphate Inhibits Proliferation and Induces Apoptosis of Colon Cancer Cells by Suppressing the AKT/mTOR Signaling Pathway
- in-vitro, CRC, NA
AntiCan↑, TumCP↓, Apoptosis↑, P21↑, p27/CDKN1B↑, Casp3↑, Casp9↑, AKT1↓, S6K↓, mTOR↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑ACC-α↑, 1,   AKT1↓, 1,   p‑AMPK↑, 1,   S6K↓, 1,   p‑S6K↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp3↑, 1,   Casp9↑, 1,   p27/CDKN1B↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

NBR2↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 2,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: S6K, S6 kinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:704  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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