cal2 Cancer Research Results

cal2, calpain-2: Click to Expand ⟱
Source:
Type:
Calpain-2 is a calcium-dependent cysteine protease that plays important roles in a variety of cellular processes, including migration, adhesion, signal transduction, and apoptosis.
In many cancer types, Calpain-2 is found to be upregulated. Elevated levels of Calpain-2 have been associated with enhanced proteolytic activity, which can contribute to cancer progression by facilitating processes such as cell migration, invasion, and metastasis.
• The increased expression of Calpain-2 in cancer cells can promote the degradation of cytoskeletal and adhesion proteins, thereby aiding in tumor cell detachment and dissemination. This is particularly relevant during epithelial-to-mesenchymal transition (EMT) and remodeling of the extracellular matrix.
• Calpain-2 activity, which is regulated by intracellular Ca²⁺ levels and calpastatin (its endogenous inhibitor), may also influence signal transduction pathways that are critical for cell proliferation and survival. Alterations in these regulatory mechanisms in a tumor setting can amplify Calpain-2’s impact.

Calpain-2 is commonly upregulated in many cancer types, and this increased expression is thought to promote tumor progression by enhancing cellular invasiveness, migration, and survival through its proteolytic actions.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
8261- LCA,    Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels
- in-vitro, CRC, T24/HTB-9
TumCP↓, ROS↑, Apoptosis↑, ER Stress↑, i-Ca+2↑, MMP↓, APAF1↑, Casp9↑, Casp3↑, cal2↑, CASP4↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CASP4↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 1,   Casp3↑, 1,   Casp9↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,  

Migration(tgid=13) ⓘ

i-Ca+2↑, 1,   cal2↑, 1,   TumCP↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: cal2, calpain-2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:1000  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page