SCFAs Cancer Research Results

SCFAs, short-chain fatty acids: Click to Expand ⟱
Source:
Type:

SCFAs are a group of small fatty acids produced mainly by microbial fermentation of dietary fibre. The principal intestinal SCFAs are acetate, propionate, and butyrate, but they differ substantially in concentration, tissue distribution, receptors, metabolism, and anticancer effects.

SCFAs ↓ often reflects dysbiosis and impaired microbial fermentation.
SCFAs ↑ or restored is commonly considered beneficial.
CRC, Colorectal Cancer: Click to Expand ⟱
Colorectal cancer is a broader term that encompasses both colon and rectal cancer.
Scientific Papers found: Click to Expand⟱
7669- IP,    Colorectal cancer and inulin supplementation: the good, the bad, and the unhelpful
- Review, CRC, NA
GutMicro↑, Buty↑, eff↓, Inflam↑, eff∅, SCFAs↑,
7656- IP,    Inulin Modulates Gut Microbiota and Increases Short-Chain Fatty Acids Levels to Inhibit Colon Tumorigenesis in Rat Models: A Systematic Review and Meta-Analysis
- Review, CRC, NA
GutMicro↑, chemoPv↑, SCFAs↑,
7660- IP,    Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans
- Review, CRC, NA
SCFAs↑, Buty↑, PA↑, TumCG↓, HDAC↓, Apoptosis↑, TumMeta↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

Buty↑, 2,   PA↑, 1,   SCFAs↑, 3,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumMeta↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↓, 1,   eff∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

GutMicro↑, 2,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SCFAs, short-chain fatty acids
3 Inulin Prebiotic
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:6  Cells:%  prod#:%  Target#:1563  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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