SIRT1 Cancer Research Results

SIRT1, Sirtuin 1 protein: Click to Expand ⟱

Source:

Type:

SIRT1 (Sirtuin 1) is a protein that plays a crucial role in various cellular processes, including metabolism, stress resistance, and longevity. In the context of cancer, SIRT1 has been found to have both tumor-suppressing and tumor-promoting functions, depending on the type of cancer and the cellular context.
Expression Promotes: Breast, Prostate, Colorectal Cancer.
Expression Suppresses: Leukemia, Liver Cancers.
-aging process is associated with the inactivation of the silent information regulator T1 (SIRT1) protein.

Alcohol, Alcohol Excess: Click to Expand ⟱

Alcohol Excess

Scientific Papers found: Click to Expand⟱

1193-

SM,

Cryptotanshinone from the Salvia miltiorrhiza Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways

in-vivo,

Alcohol,

mice

in-vitro,

Liver,

HepG2

*p‑AMPK↑, *SIRT1↑, *NRF2↑, *CYP2E1↓, *lipoGen↓, *ROS↓, *Inflam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

CYP2E1↓, 1, NRF2↑, 1, ROS↓, 1,

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1, lipoGen↓, 1, SIRT1↑, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,
Total Targets: 7

Scientific Paper Hit Count for: SIRT1, Sirtuin 1 protein

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells