p38 Cancer Research Results

p38, p38: Click to Expand ⟱

Source:

Type:

P38, or p38 MAPK (p38 mitogen-activated protein kinase), is a protein kinase that plays a significant role in cellular responses to stress, inflammation, and apoptosis (programmed cell death). It is part of the MAPK signaling pathway, which is involved in various cellular processes, including cell growth, differentiation, and survival.
It can have both tumor-suppressive and tumor-promoting effects, depending on the type of cancer and the cellular context.

-p38 activation can contribute to tumor progression by influencing inflammatory signaling and cell-cycle regulation.
-Overexpression can correlate with poor prognosis in some studies.

Diabetic, Diabetic: Click to Expand ⟱

Diabetic

Scientific Papers found: Click to Expand⟱

2690-

BBR,

Berberine Differentially Modulates the Activities of ERK, p38 MAPK, and JNK to Suppress Th17 and Th1 T Cell Differentiation in Type 1 Diabetic Mice

in-vivo,

Diabetic,

berberine (Sigma, 200 mg/kg body weight), by gavage, daily for 2 weeks

11-week-old female NOD mice

*Inflam↓, *Th17↓, *Th1 response↓, *ERK↑, *p38↓, *JNK↓, *STAT1↓, *STAT4↓, *MAPK↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Cell Death ⓘ

JNK↓, 1, MAPK↓, 1, p38↓, 1,

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1, STAT1↓, 1, STAT4↓, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1, Th1 response↓, 1, Th17↓, 1,
Total Targets: 9

Scientific Paper Hit Count for: p38, p38

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells