PGC-1α Cancer Research Results

PGC-1α, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha: Click to Expand ⟱

Source:

Type: transcriptional coactivator

PGC-1α (Peroxisome proliferator-activated receptor gamma coactivator 1-alpha) is a transcriptional coactivator that plays a crucial role in regulating cellular energy metabolism, including mitochondrial biogenesis and function. PGC-1α is also involved in various cellular processes, including cell growth, differentiation, and survival.

In some cancers (for example, certain melanomas, breast cancers, and prostate cancers), elevated levels of PGC-1α have been observed.
– Increased PGC-1α may enhance mitochondrial function and support the energetic and biosynthetic demands of tumor cells, especially under metabolic stress or during metastasis.

Diabetic, Diabetic: Click to Expand ⟱

Diabetic

Scientific Papers found: Click to Expand⟱

2395-

EGCG,

EGCG inhibits diabetic nephrophathy through up regulation of PKM2

Study,

Diabetic,

*PKM2↑, *Apoptosis↓, *PGC-1α↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Mitochondria & Bioenergetics ⓘ

PGC-1α↑, 1,

Core Metabolism/Glycolysis ⓘ

PKM2↑, 1,

Cell Death ⓘ

Apoptosis↓, 1,
Total Targets: 3

Scientific Paper Hit Count for: PGC-1α, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells