NLRP3 Cancer Research Results

NLRP3, NOD-like receptor pyrin domain-containing protein 3: Click to Expand ⟱

Source:

Type:

NLRP3 (NOD-like receptor pyrin domain-containing protein 3) is a protein that plays a crucial role in the regulation of inflammation and immune responses.
NLRP3 typically has high expression in cancers, with poor prognosis.
For alzheimer's disease:
-NLRP3 is upregulated in Alzheimer's disease (AD)
-NLRP3 is activated in microglia in response to amyloid-β (Aβ) and tau aggregates.
-Promotes tau hyperphosphorylation and spread via inflammation-driven pathways.

ostP, Osteoporosis: Click to Expand ⟱

Osteoporosis

Scientific Papers found: Click to Expand⟱

3472-

MF,

NLRP3Caspase1GSDMD_signaling_path">Pulsed electromagnetic field alleviates synovitis and inhibits the NLRP3/Caspase-1/GSDMD signaling pathway in osteoarthritis rats

in-vivo,

ostP,

3.82 mT, 8 Hz, 40 min/day, 5 days a week, for 12 weeks.

three-month-old Sprague-Dawley (SD)

*Inflam↓, *NLRP3↓, *Casp1↓, *GSDMD?,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Cell Death ⓘ

Casp1↓, 1, GSDMD?, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,

Protein Aggregation ⓘ

NLRP3↓, 1,
Total Targets: 4

Scientific Paper Hit Count for: NLRP3, NOD-like receptor pyrin domain-containing protein 3

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells