COL3A1 Cancer Research Results

COL3A1, collagen3a: Click to Expand ⟱
Source:
Type:
COL3A1 encodes a component of type III collagen—a major structural protein in the extracellular matrix.

Elevated COL3A1 expression has frequently been observed in solid tumors and is often associated with a desmoplastic response.
There is a recurring observation across multiple tumor types that increased COL3A1 expression in the tumor stroma is linked to worse clinical outcomes, including more advanced stage and lower survival rates.
LiverDam, Liver Damage: Click to Expand ⟱
Liver Damage
Scientific Papers found: Click to Expand⟱
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↑, 1,   ROS↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,  

Migration ⓘ

COL1↓, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   Fibronectin↓, 1,   MMP2↓, 1,   Smad7↑, 1,   TGF-β↓, 1,   Vim↓, 1,   α-SMA↓, 2,  

Functional Outcomes ⓘ

hepatoP↑, 1,  
Total Targets: 14

Scientific Paper Hit Count for: COL3A1, collagen3a
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:66  Cells:%  prod#:%  Target#:1057  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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