COL3A1 Cancer Research Results

COL3A1, Collagen Type III Alpha 1 Chain / Collagen III: Click to Expand ⟱
Source:
Type:

COL3A1 - Collagen Type III Alpha 1 Chain / Collagen III

Abbreviation: COL3A1, Collagen III, Type III Collagen

Type: Extracellular matrix structural protein / fibrillar collagen

Function: Collagen III is a fibrillar extracellular-matrix protein composed primarily of COL3A1 chains. It is abundant in connective tissues and commonly associates with type I collagen. Collagen III contributes to tissue tensile strength, extracellular-matrix organization, wound healing, fibrosis, cell adhesion, and mechanical signaling through receptors including integrins and discoidin domain receptors.

Cancer: ↑ Frequently increased in tumor-associated extracellular matrix and desmoplastic stroma. Elevated COL3A1/collagen III can reflect cancer-associated fibroblast activation and extracellular-matrix remodeling and may promote tumor-cell adhesion, migration, invasion, metastatic dissemination, and altered mechanotransduction. High COL3A1 expression is associated with aggressive disease and poor prognosis in several cancers, although effects depend on tumor type and matrix organization.
LiverDam, Liver Damage: Click to Expand ⟱
Liver Damage
Scientific Papers found: Click to Expand⟱
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   GSH↑, 1,   ROS↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,  

Migration(tgid=13) ⓘ

COL1↓, 1,   COL3A1↓, 1,   E-cadherin↑, 1,   Fibronectin↓, 1,   MMP2↓, 1,   Smad7↑, 1,   TGF-β↓, 1,   Vim↓, 1,   α-SMA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,  
Total Targets: 14

Scientific Paper Hit Count for: COL3A1, Collagen Type III Alpha 1 Chain / Collagen III
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:66  Cells:%  prod#:%  Target#:1057  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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