ARE Cancer Research Results

ARE, antioxidant responsive element (ARE): Click to Expand ⟱

Source:

Type:

antioxidant responsive element (ARE)
ARE in Normal Cells: Protective Role
ARE-regulated genes include NQO1, HO-1, GCLM, GCLC, and various glutathione S-transferases (GSTs).
-Detoxify reactive oxygen species (ROS)
-Agents like sulforaphane (from broccoli) can activate ARE in healthy cells to prevent cancer initiation.
-overactivation in cancer cells aids cancer survival, growth, resistance

Park, Parkinson's Disease (PD): Click to Expand ⟱

Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, and is due to the degeneration of dopaminergic neurons. It is multifactorial, caused by genetic and environmental factors and currently has no definitive cure.
-CoQ10 deficiency was observed at a higher frequency in Parkinson's disease

Scientific Papers found: Click to Expand⟱

4265-

CA,

Potential applications of nanomedicine for treating Parkinson's disease

Review,

Park,

*NRF2↑, *ARE↑, *neuroP↑, *motorD↑, *cognitive↑, *SOD↑, *GSR↑, *NGF↑, *BDNF↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

ARE↑, 1, GSR↑, 1, NRF2↑, 1, SOD↑, 1,

Synaptic & Neurotransmission ⓘ

BDNF↑, 1, NGF↑, 1,

Functional Outcomes ⓘ

cognitive↑, 1, motorD↑, 1, neuroP↑, 1,
Total Targets: 9

Scientific Paper Hit Count for: ARE, antioxidant responsive element (ARE)

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells