Beclin-1 Cancer Research Results
Beclin-1, Beclin-1 (BECN1 gene): Click to Expand ⟱
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| Type: Protein Coding gene |
Beclin 1, an autophagy and haploinsufficient tumor-suppressor protein, is frequently monoallelically deleted in breast and ovarian cancers. However, the precise mechanisms by which Beclin 1 inhibits tumor growth remain largely unknown.
A key biomarker of autophagy is Beclin-1. Beclin-1 stimulates LC3-I’s lipidation to produce LC3-II, which localizes to the autophagosome membrane to activate the development of autophagosomes.
-BECN1 = the official gene symbol (human gene name)
-Beclin-1 = the protein name encoded by the BECN1 gene
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Park, Parkinson's Disease (PD): Click to Expand ⟱
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor and non-motor symptoms, and is due to the degeneration of dopaminergic neurons. It is multifactorial, caused by genetic and environmental factors and currently has no definitive cure.
-CoQ10 deficiency was observed at a higher frequency in Parkinson's disease
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Scientific Papers found: Click to Expand⟱
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proCasp9↓, CDC2↓, CycB/CCNB1↓, Casp9↑, Casp3↑, Cyt‑c↑, cycA1/CCNA1↑, CDK2↓, APAF1↑, TumCCA↑, P53↑, BAX↑, VEGF↓, Bcl-2↓, Apoptosis↑, p‑Akt↓, p‑EGFR↓, p‑ERK↓, p‑STAT3↓, cardioP↑, Catalase↓, SOD↓, *BioAv↓, *antiOx↑, *ROS↓, *NO↓, *GSTs↑, *GSR↑, *SOD↑, *Catalase↑, *lipid-P↓, PI3K↓, Akt↓, CDK2↓, BNIP3↑, hTERT/TERT↓, DR5↑, Beclin-1↑, TNF-α↓, NF-kB↓, IL1↓, IL6↓, EMT↓, FAK↓, E-cadherin↑, MDM2↓, NOTCH↓, MAPK↑, Vim↓, N-cadherin↓, Snail↓, MMP2↓, Twist↓, MMP9↓, ROS↑, MMP↓, *AChE↓, *MMP↑, *Aβ↓, *neuroP↑, Trx1↑, ROS↓, *NRF2↑, NRF2↓, *BBB↑, ChemoSen↑, GutMicro↑,
Showing Research Papers: 1 to 1 of 1
* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1
Pathway results for Effect on Cancer / Diseased Cells:
Redox & Oxidative Stress ⓘ
Catalase↓, 1, NRF2↓, 1, ROS↓, 1, ROS↑, 1, SOD↓, 1, Trx1↑, 1,
Mitochondria & Bioenergetics ⓘ
CDC2↓, 1, MMP↓, 1,
Cell Death ⓘ
Akt↓, 1, p‑Akt↓, 1, APAF1↑, 1, Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1, Casp3↑, 1, Casp9↑, 1, proCasp9↓, 1, Cyt‑c↑, 1, DR5↑, 1, hTERT/TERT↓, 1, MAPK↑, 1, MDM2↓, 1,
Autophagy & Lysosomes ⓘ
Beclin-1↑, 1, BNIP3↑, 1,
DNA Damage & Repair ⓘ
P53↑, 1,
Cell Cycle & Senescence ⓘ
CDK2↓, 2, cycA1/CCNA1↑, 1, CycB/CCNB1↓, 1, TumCCA↑, 1,
Proliferation, Differentiation & Cell State ⓘ
EMT↓, 1, p‑ERK↓, 1, NOTCH↓, 1, PI3K↓, 1, p‑STAT3↓, 1,
Migration ⓘ
E-cadherin↑, 1, FAK↓, 1, MMP2↓, 1, MMP9↓, 1, N-cadherin↓, 1, Snail↓, 1, Twist↓, 1, Vim↓, 1,
Angiogenesis & Vasculature ⓘ
p‑EGFR↓, 1, VEGF↓, 1,
Immune & Inflammatory Signaling ⓘ
IL1↓, 1, IL6↓, 1, NF-kB↓, 1, TNF-α↓, 1,
Drug Metabolism & Resistance ⓘ
ChemoSen↑, 1,
Clinical Biomarkers ⓘ
p‑EGFR↓, 1, GutMicro↑, 1, hTERT/TERT↓, 1, IL6↓, 1,
Functional Outcomes ⓘ
cardioP↑, 1,
Total Targets: 54
Pathway results for Effect on Normal Cells:
Redox & Oxidative Stress ⓘ
antiOx↑, 1, Catalase↑, 1, GSR↑, 1, GSTs↑, 1, lipid-P↓, 1, NRF2↑, 1, ROS↓, 1, SOD↑, 1,
Mitochondria & Bioenergetics ⓘ
MMP↑, 1,
Angiogenesis & Vasculature ⓘ
NO↓, 1,
Barriers & Transport ⓘ
BBB↑, 1,
Synaptic & Neurotransmission ⓘ
AChE↓, 1,
Protein Aggregation ⓘ
Aβ↓, 1,
Drug Metabolism & Resistance ⓘ
BioAv↓, 1,
Functional Outcomes ⓘ
neuroP↑, 1,
Total Targets: 15
Scientific Paper Hit Count for: Beclin-1, Beclin-1 (BECN1 gene)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include :
-low or high Dose
-format for product, such as nano of lipid formations
-different cell line effects
-synergies with other products
-if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:75 Cells:% prod#:% Target#:30 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid
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