GPx Cancer Research Results

GPx, Glutathione peroxidases: Click to Expand ⟱

Source:

Type:

Glutathione peroxidases (GPXs) are crucial antioxidant enzymes, counteracting reactive oxygen species (ROS).
Glutathione peroxidase (GPx) refers to a family of antioxidant enzymes that play a crucial role in protecting cells from oxidative stress by catalyzing the reduction of hydrogen peroxide and organic peroxides. There are several isoforms of GPx, including GPx1, GPx2, GPx3, and GPx4, each with distinct tissue distributions and functions.
GPX overexpression promotes proliferation and invasion in cancer cells. Glutathione peroxidase-1 (GPX1), the most abundant isoform, contributes to invasion, migration, cisplatin resistance, and proliferation in various cancers.

GPx expression is often elevated in various cancers and is generally associated with poorer prognosis due to its role in protecting cancer cells from oxidative stress and contributing to treatment resistance.

fibroS, Fibrosarcoma: Click to Expand ⟱

Fibrosarcoma is a malignant tumor that arises from fibroblasts, the connective tissue cells responsible for producing collagen and other components of the extracellular matrix.

Scientific Papers found: Click to Expand⟱

2204-

erastin,

Regulation of ferroptotic cancer cell death by GPX4

in-vitro,

fibroS,

HT1080

GSH↓, Ferroptosis↑, ROS↑, GPx↓, GPx4↓, lipid-P↑, eff↓, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1, GPx↓, 1, GPx4↓, 1, GSH↓, 1, lipid-P↑, 1, ROS↑, 1,

Cell Death ⓘ

Ferroptosis↑, 1,

Drug Metabolism & Resistance ⓘ

eff↓, 1, eff↑, 1,
Total Targets: 9

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GPx, Glutathione peroxidases

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells