EPR Cancer Research Results

EPR, enhanced permeability and retention (EPR) effect: Click to Expand ⟱
Source:
Type:
Passive accumulation (in cells) is based on the unique architecture of the tumor tissue, where neo-angiogenesis leads to an atypical endothelial layer and to fenestrated vasculature, which together with the impaired lymphatic drainage guides the penetration and accumulation of nano-sized materials within the cancerous tissues.
Exploited for drug design in the nanomedicine field.
BPH, Benign Prostatic Hyperplasia: Click to Expand ⟱
Benign Prostatic Hyperplasia (BPH) is a noncancerous enlargement of the prostate gland that commonly occurs in older men.
- Increased DHT levels in prostatic tissue are associated with hyperplasia.
- An imbalance in IGF signaling might contribute to abnormal growth.
- Targeted therapies (such as 5α-reductase inhibitors and α-blockers).
Scientific Papers found: Click to Expand⟱
5975- AgNPs,  PDT,  CDT,  RF,    Recent Advances in the Application of Silver Nanoparticles for Enhancing Phototherapy Outcomes
- Review, Var, NA - Review, BPH, NA
ROS↑, EPR↓, eff↑, Bacteria↓, eff↑, eff↑, TumVol↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Angiogenesis & Vasculature ⓘ

EPR↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 3,  

Functional Outcomes ⓘ

TumVol↓, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EPR, enhanced permeability and retention (EPR) effect
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:86  Cells:%  prod#:%  Target#:612  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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