ATF2 Cancer Research Results

ATF2, Activating Transcription Factor 2: Click to Expand ⟱
Source:
Type:
ATF2 (Activating Transcription Factor 2)
-ATF2 is a member of the ATF/CREB (cyclic AMP response element‐binding protein) family of transcription factors.
-It functions by binding to specific DNA sequences to regulate the transcription of a variety of target genes involved in cell proliferation, stress response, apoptosis, and differentiation.
-ATF2 activity is regulated through phosphorylation by stress-activated protein kinases such as JNK, p38, and ERK, integrating signals from various cellular stressors.

-Increased ATF2 activity in certain lung cancer subtypes has been linked with increased invasiveness and metastatic potential.
Covid, Covid: Click to Expand ⟱
Covid

Scientific Papers found: Click to Expand⟱
5463- AF,    Will Auranofin Become a Golden New Treatment Against COVID-19?
- Review, Covid, NA
IL6↓, NF-kB↓, ATF2↓, TrxR↓, ROS↑, Apoptosis↑, IL6↓, Dose↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,   TrxR↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   ATF2↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL6↓, 2,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 2,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ATF2, Activating Transcription Factor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:87  Cells:%  prod#:%  Target#:1295  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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