BCR-ABL Cancer Research Results

BCR-ABL, BCR-ABL: Click to Expand ⟱
Source:
Type:
BCR‑ABL is a well‐characterized fusion oncoprotein resulting from a chromosomal translocation that has significant diagnostic, prognostic, and therapeutic relevance in hematologic malignancies.

– It promotes uncontrolled cell proliferation, inhibits apoptosis, and contributes to genomic instability.
– Quantitative measurement of BCR‑ABL transcript levels is used to monitor minimal residual disease (MRD) and predict response to therapy.

– BCR‑ABL is not only a diagnostic hallmark of CML and certain ALL cases but also a critical driver of disease progression that can be effectively targeted by molecular therapies.
CML, Chronic Myeloid Leukemia: Click to Expand ⟱
Chronic Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
7578- IMA,    Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia
- Trial, CML, NA
OS↑, toxicity↓, BCR-ABL↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   toxicity↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: BCR-ABL, BCR-ABL
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:91  Cells:%  prod#:%  Target#:1075  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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