Cancer Database Query Results

CML, Chronic Myeloid Leukemia: Click to Expand ⟱
Chronic Myeloid Leukemia
Scientific Papers found: Click to Expand⟱
7184- CHA,    Chaetocin antileukemia activity against chronic myelogenous leukemia cells is potentiated by bone marrow stromal factors and overcomes innate imatinib resistance
- in-vitro, CML, NA
ROS↑, TrxR↓, eff↓, eff↑,
6592- DAS,    Final 5-Year Study Results of DASISION: The Dasatinib Versus Imatinib Study in Treatment-Naïve Chronic Myeloid Leukemia Patients Trial
- Trial, CML, NA
Dose↝, other↝, OS↑,
7545- HYP,    Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2
- in-vitro, CML, K562
xCT/SLC7A11↓, GPx4↓, Ferroptosis↑, ROS↑, lipid-P↑, mtDam↑, NRF2↓,
7578- IMA,    Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia
- Trial, CML, NA
OS↑, toxicity↓, BCR-ABL↓,
7719- IP6,    Effect of inositol hexaphosphate (IP(6)) on human normal and leukaemic haematopoietic cells
- in-vitro, CML, NA
TumCD↑, TumCCA↑, selectivity↑, TumCP↓,
8046- IVM,    Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress
- in-vitro, CML, NA
TumCD↑, mtDam↑, ROS↓, selectivity↑, compI↓, mitResp↓, eff↓,

Showing Research Papers: 1 to 6 of 6

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

compI↓, 1,   Ferroptosis↑, 1,   GPx4↓, 1,   lipid-P↑, 1,   NRF2↓, 1,   ROS↓, 1,   ROS↑, 2,   TrxR↓, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

BCR-ABL↓, 1,   mitResp↓, 1,   mtDam↑, 2,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,   TumCD↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↓, 2,   eff↑, 1,   selectivity↑, 2,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 2,   toxicity↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:91  Cells:%  prod#:%  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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