SFXN2 Cancer Research Results

SFXN2, Sideroflexin 2: Click to Expand ⟱
Source:
Type:

SFXN2 - Sideroflexin 2

Type: Mitochondrial transmembrane protein / sideroflexin family member / mitochondrial iron-regulation protein

Function: SFXN2 is a mitochondrial membrane protein involved in mitochondrial iron homeostasis, heme biosynthesis, mitochondrial respiration, redox regulation, and mitophagy. Loss of SFXN2 can cause mitochondrial iron accumulation, reduced heme content, impaired heme-dependent enzyme activity, and mitochondrial respiratory dysfunction.

Cancer: ↑ Increased SFXN2 has been associated with tumor-supportive mitochondrial metabolism in selected cancers. In multiple myeloma, SFXN2 is elevated and promotes proliferation while suppressing starvation-induced autophagy and mitophagy. SFXN2 inhibition or knockdown disrupts mitochondrial iron metabolism, increases mitochondrial damage and mitophagy, and suppresses tumor growth. Increased SFXN2 has also been reported in prostate cancer, although its cancer role remains tissue-dependent and less broadly characterized than many established oncogenic targets.
Mye, Myeloma: Click to Expand ⟱

Myeloma - Plasma Cell Malignancy

Alternative Names: Multiple myeloma, plasma cell myeloma

Type: Hematologic malignancy / plasma cell cancer

Origin: Malignant transformation and clonal expansion of antibody-producing plasma cells, usually within the bone marrow.

Function/Characteristics: Myeloma cells produce monoclonal immunoglobulins or light chains and can disrupt normal bone marrow function, bone remodeling, renal function, and immune regulation.

Common Features: Bone marrow infiltration, osteolytic bone lesions, anemia, elevated monoclonal protein, renal dysfunction, hypercalcemia, and impaired normal antibody production.

Common Markers: CD38, CD138, BCMA (TNFRSF17), SLAMF7, and monoclonal immunoglobulin/light-chain expression.
Scientific Papers found: Click to Expand⟱
8078- KAE,    Kaempferol induces mitophagy and disrupts iron metabolism via SFXN2 leading to apoptosis in multiple myeloma cells
- in-vitro, Mye, NA
TumCP↓, Apoptosis↑, mtDam↑, mt-TumAuto↑, i-Iron↑, SFXN2↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

SFXN2↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

i-Iron↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

mt-TumAuto↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SFXN2, Sideroflexin 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:92  Cells:%  prod#:%  Target#:1757  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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