IκB Cancer Research Results

IκB, IκB kinase(α): Click to Expand ⟱
Source:
Type:
IκB (Inhibitor of Nuclear Factor kappa B) proteins are critical regulators of the NF-κB signaling pathway, which plays a significant role in inflammation, immune response, and cell survival.
IκB kinase/NF-κB (IKK/NF-κB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-κB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells.
NFKB inhibitor α (IκB‑α) acts as a negative regulator of the classical NF‑κB pathway through its ability to maintain the presence of NF‑κB in the cytoplasm.
IκB (Inhibitor of κB) proteins play a crucial role in regulating the NF-κB (Nuclear Factor kappa-light-chain-enhancer of activated B cells) signaling pathway, which is involved in various cellular processes, including inflammation, immune response, and cell survival. The NF-κB pathway is tightly regulated, and its dysregulation has been implicated in the development and progression of various cancers.
In many cancers, the degradation of IκB is enhanced, leading to constitutive activation of NF-κB. This can promote tumor growth and survival by upregulating genes involved in cell proliferation and anti-apoptotic factors.

IκB proteins generally act as tumor suppressors by inhibiting NF-κB activity. When IκB is downregulated, NF-κB is activated, leading to increased cell proliferation, survival, and inflammation, which can promote tumor growth.

It is generally down regulated in cancers, with poorer prognosis.
Scientific Papers found: Click to Expand⟱
8236- LE,    Licorice (Glycyrrhiza glabra L.)-Derived Phytochemicals Target Multiple Signaling Pathways to Confer Oncopreventive and Oncotherapeutic Effects
- Review, Var, NA
Bcl-2↓, Multiple licorice constituents have been shown to bind to and inhibit the activities of various cellular targets, including B-cell lymphoma 2, cyclin-dependent kinase 2, phosphatidylinositol 3-kinase, c-Jun N-terminal kinases, mammalian target of rap
CDK2↓,
PI3K↓,
cJun↓,
mTOR↓,
NF-kB↓, nuclear factor-κB, signal transducer and activator of transcription 3, vascular endothelial growth factor, and matrix metalloproteinase-3, resulting in reduced carcinogenesis in several in vitro and in vivo models with no evident toxicity
VEGF↓,
MMP3↓,
toxicity↓,
Dose↑, European Union established a temporary upper limit of 100 mg/day for glycyrrhizin consumption (about the amount found in 60–70 g licorice).
chemoP↑, Licorice has long been used as an antidote to counteract the toxicity of chemotherapeutic treatment
*antiOx↑, including antioxidant and anti-inflammatory properties, as well as a protective effect on several organs
*Inflam↓,
Dose↝, The main sweet-tasting ingredient of G. glabra (licorice) root is glycyrrhizin (or glycyrrhizinic acid or GA).
*COX2/PTGS2↓, glycyrrhizin and 18β-glycyrrhetinic acid have been defined by different investigators as significant inhibitors of inflammatory factors, such as cyclooxygenase-2 (COX-2), HMGP 1, inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), IL-10, t
*iNOS↓,
*IL6↓,
*IL10↓,
*PGE2↓, licochalcone A and licochalcone B inhibit IL-6 and PGE2 in LPS-induced macrophage cells,
*IκB?, isoliquiritigenin and isoliquiritin inhibit inhibitory κBα (IκBα) phosphorylation and degradation, and increase the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 in LPS-induced macrophage cells
*NRF2↑,
*HO-1↑,
*lipid-P↓, figure 2
*ROS↓,
*Catalase↑,
*GPx↑,
*SOD↑,
Apoptosis↑, The glycyrrhetinic acid and its derivatives induce mitochondrial-mediated apoptosis in cancer cells, as it was found in a study conducted by Lin et al119 where apoptosis was induced by the generation of reactive oxygen species (ROS)
ROS↑,
TumCP↓, GA, another flavonoid extracted from the roots of licorice also induces apoptosis and suppresses the proliferation of MDA-MB-231 breast cancer cells by increased generation of ROS.123
TumCCA↑, GA induces cell cycle arrest at G1/S phase in gastric cancer cells by downregulating the cyclin E1, cyclin E2, and cyclin D1-3 levels causing cell death in these cancer cells.
cycE/CCNE↓,
cycD1/CCND1↓,
p‑GSK‐3β↓, SK-MEL-28 and SK-MEL-5 Induced apoptosis ↓G1 phase, ↓cyclin D1, ↓cyclin E, ↓p-Akt, ↓p-GSK3β, ↓p-JNK1/2, ↓PI3K, ↓MKK4, ↓MKK7
PI3K↓,
MKK4↓,
MKK7↓,
HSP90↓, HT-29 Induced apoptosis ↓Proliferation, ↓viability of cells, ↑cell death of cancer cells, ↓HSP90
LC3‑Ⅱ/LC3‑Ⅰ↑, MKN28 Inhibited metastasis ↓Proliferation and metastasis, ↓migration and invasion, ↑LC3II/LC3I ratio, ↑Beclin 1, ↓p62, ↓p-Akt, ↓p- mTOR
Beclin-1/ATG6↑,
p62↓,
p‑Akt↓,
cl‑Casp9↑, Caki Induced apoptosis ↑Cleavage of caspase-9, caspase-7 and caspase-3, and PARP, ↑Bax, ↓Bcl-2, ↓ Bcl-xL, ↑cyt. c release, ↑p53, ↓MDM2, ↑ROS levels, ↓STAT3, ↓cyclin D1 and D2, ↓p-JAK2,
cl‑Casp7↑,
cl‑Casp3↑,
cl‑PARP↑,
BAX↑,
Cyt‑c↑,
P53↑,
STAT3↓,
E-cadherin↑, ↑E-cadherin ↓Vimentin, ↓N-cadherin,
Vim↓,
N-cadherin↓,
CD31/PECAM-1↓, ↓VEGF-A, ↓CD31 ↓HIF-1α, ↓iNOS, ↓COX-2
Hif1a↓,
iNOS↓,
DNAdam↑, ↑Nuclear condensation, ↑ nuclear fragmentation, ↑ apoptotic ratio, ↑decrease in the ΔΨ m, ↑Bax, ↑ Bim, ↑Apaf-1, ↑caspase-9, ↑caspase-3, ↓Bcl-2, ↑CDK2
MMP↓,
BIM↑,
APAF1↑,
PCNA↓, ↓PCNA, ↓MMP2, ↓ MMP9, ↑caspase-3, ↓p-PI3K, ↓p-Akt
toxicity↝, In addition, based on a case report, excessive consumption of licorice may also lead to toxic consequences in the form of thrombocytopenia.
eff↑, A clinical stage II preliminary trial revealed that licorice root extract in combination with docetaxel works in treating patients with hormonal therapy resistant metastatic prostate tumors


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MKK4↓, 1,   MKK7↓, 1,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   BIM↑, 1,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   iNOS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑GSK‐3β↓, 1,   mTOR↓, 1,   PI3K↓, 2,   STAT3↓, 1,  

Migration(tgid=13) ⓘ

CD31/PECAM-1↓, 1,   E-cadherin↑, 1,   MMP3↓, 1,   N-cadherin↓, 1,   TumCP↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↑, 1,   Dose↝, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,  
Total Targets: 47

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↓, 1,   IL6↓, 1,   Inflam↓, 1,   IκB?, 1,   PGE2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 16

Scientific Paper Hit Count for: IκB, IκB kinase(α)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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