XIAP Cancer Research Results

XIAP, X-linked inhibitor of apoptosis protein (XIAP) baculoviral IAP repeat-containing protein 4 (BIRC4): Click to Expand ⟱
Source:
Type:
Also known as BIRC4. XIAP is inhibited by DIABLO (Smac) and HTRA2 (Omi), two death-signaling proteins released into the cytoplasm by the mitochondria.
High proportions of XIAP may function as a tumor marker. In developing prostate cancer, XIAP is one of four IAPs overexpressed in the prostatic epithelium.

XIAP functions predominantly as a protumorigenic protein in the context of cancer. Its upregulation is commonly observed in various tumor types and is associated with poor patient outcomes and resistance to therapy due to its potent inhibition of apoptosis.
Scientific Papers found: Click to Expand⟱
8151- lamb,    Suppression of STAT3 Phosphorylation and RelA/p65 Acetylation Mediated by MicroRNA134 Plays a Pivotal Role in the Apoptotic Effect of Lambertianic Acid
- in-vitro, BC, MCF7 - in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, BC, MDA-MB-231
TumCCA↑, LA significantly increased the cytotoxicity, sub G 1 population, and the cleavage of poly (ADP-ribose) polymerase (PARP) in MDA-MB-453 or PC-3 cells (STAT3 mutant), more than in the MCF-7 or DU145 cells (STAT3 wild)
cl‑PARP↑,
p‑STAT3↓, LA inhibited the phosphorylation of STAT3 and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)
NF-kB↓,
XIAP?, also suppressed the protein expression of XIAP, survivin, Bcl-2, Bcl-xL, vascular endothelial growth factor (VEGF), Cox-2, c-Myc and mRNA expression of interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) in MCF-7 cells.
survivin↓,
Bcl-2↓,
Bcl-xL↓,
VEGF↓,
COX2/PTGS2↓,
cMyc↓,
IL6↓,
TNF-α↓,
ac‑p65↑, Overall, these findings suggest that LA induced apoptosis via the miRNA-134 mediated inhibition of STAT3 and RelA/p65 acetylation.
Obesity↓,
miR-134↑, LA increased the expression of miR134 in the MCF-7 cells


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

miR-134↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP?, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   Bcl-xL↓, 1,   survivin↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑STAT3↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL6↓, 1,   NF-kB↓, 1,   ac‑p65↑, 1,   TNF-α↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Obesity↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: XIAP, X-linked inhibitor of apoptosis protein (XIAP) baculoviral IAP repeat-containing protein 4 (BIRC4)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

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